Top 20 Research Peptides: Metabolic, Obesity, Healing, Brain Nootropic function
Top 5 Research Peptides for Metabolic, Obesity, Healing & Nootropic Focus
Twenty frequently studied peptides, organized by research focus—plus mechanisms, typical research ranges, and study notes. For laboratory research only. Not for human use.
Top 5 Peptides — Metabolic Focus
Goal: pathways tied to insulin sensitivity, mitochondrial efficiency, AMPK signaling, and nutrient partitioning.
MOTS-c
MitochondrialAMPK
MT-encoded peptide explored for effects on AMPK activation, metabolic resilience, and exercise-like signaling in preclinical settings.
Typical research ranges: 5–15 mg per study cycle (animal models). See protocol literature for specific paradigms.
5-Amino-1MQ
NAD+ / NNMTAdipocyte metabolism
Small-molecule peptide-adjacent inhibitor of NNMT studied for adipocyte energy expenditure and lipid handling in models.
Typical research ranges: 25–75 mg per cycle (animal data). Literature varies; follow study-specific methods.
SS-31 (Elamipretide)
CardiolipinMitochondria
Cell-penetrating tetrapeptide that targets cardiolipin to support electron transport efficiency in experimental models.
Typical research ranges: 2–10 mg per study week (varies by model and route).
CJC-1295 + Ipamorelin
GH/IGF-1 axisSynergy
Commonly co-studied to evaluate pulsatile GH signaling and downstream metabolic readouts in vivo.
Typical research ranges: low-mg weekly totals per peptide; timing protocols vary widely in literature.
FGF21 Analogs
HepaticGlucose & Lipids
FGF21-pathway agonism is investigated for effects on glucose homeostasis and lipid profiles in preclinical models.
Typical research ranges: model-dependent; consult protocol references.
Top 5 Peptides — Obesity Focus
Goal: appetite signaling, energy expenditure, adipose vasculature, and multi-agonist incretin pathways.
Semaglutide (GLP-1 RA)
GLP-1Appetite signaling
GLP-1 receptor agonism studied for satiety and gastric emptying kinetics in controlled models.
Typical research ranges: model-specific micro- to low-mg schedules; verify protocol literature.
Tirzepatide (GLP-1/GIP)
Dual agonistEnergy balance
Dual GLP-1/GIP agonism explored for additive effects on energy intake and glucose handling in preclinical studies.
Typical research ranges: low-mg weekly equivalents (animal studies).
Retatrutide (GLP-1/GIP/Glucagon)
Tri-agonistThermogenesis
Tri-agonist approach studied for combined satiety and energy expenditure endpoints.
Typical research ranges: tightly model-bound; consult primary references.
AOD-9604
GH fragmentAdipocyte focus
Investigated in models for lipolytic signaling distinct from classical GH effects.
Typical research ranges: mg-scale per cycle in animal models; protocols vary.
Adipotide (FTPP)
Adipose vasculatureTargeted
Targeting of adipose vasculature studied for selective effects on white fat depots in animals.
Typical research ranges: model-dependent; follow ethical and safety guidelines.
Top 5 Peptides — Healing & Tissue Support
Goal: tissue integrity, angiogenesis signaling, extracellular matrix support, and epithelial balance.
BPC-157
Gastro-tendonAngiogenic balance
Widely studied in animals for soft-tissue and GI tract models; often evaluated for microvascular and tendon parameters.
Typical research ranges: micro- to low-mg daily/weekly equivalents in animal settings.
TB-500 (Thymosin β4 fragment)
Actin dynamicsAngiogenesis
Explored for actin-binding and cellular migration effects relevant to tissue models.
Typical research ranges: mg-scale loading phases in animal models, then reduced maintenance.
GHK-Cu
Copper peptideECM support
Peptide-copper complex studied for collagen matrix signaling and dermal remodeling endpoints in vitro and in vivo.
Typical research ranges: concentration-based topical studies; mg-scale for solution prep.
KPV (α-MSH fragment)
EpithelialInflammatory balance
Evaluated for epithelial integrity models and inflammatory signaling modulation.
Typical research ranges: micro- to low-mg equivalents; topical and systemic paradigms exist in literature.
LL-37
CathelicidinBarrier function
Endogenous peptide investigated for host-defense and wound-environment parameters in controlled studies.
Typical research ranges: μg–mg-scale depending on matrix and model.
Top 5 Peptides — Nootropic Focus
Goal: neurotrophic signaling, BDNF pathways, stress-response balance, and synaptic plasticity (preclinical models).
Semax
ACTH(4-7)BDNF expression
Studied for neurotrophic and cognitive endpoints; literature explores attention and stress-axis balance in models.
Typical research ranges: concentration-based paradigms in animal and cell studies.
Selank
Tuftsin analogGABAergic balance
Explored for anxiolytic-like readouts and memory endpoints via GABA-related pathways in preclinical work.
Typical research ranges: similar to Semax; consult specific study designs.
Dihexa
HGF/c-MetSynaptogenesis
Peptidomimetic examined for effects on synaptic density and memory tasks in animal models.
Typical research ranges: μg–mg-scale per day in model-specific paradigms.
P-21
Cerebrolysin-derivedNGF/BDNF axes
Fragment-based peptide studied for neurotrophic support and memory-task performance in preclinical settings.
Typical research ranges: low-mg totals across study windows (model-dependent).
Noopept
DipeptideNeuroprotection
Dipeptidic compound researched for cognitive and neuroprotective endpoints; often included in peptide-adjacent stacks.
Typical research ranges: μg–mg-scale daily equivalents depending on route/model.
Related Reads
- Mitochondrial Peptides: MOTS-c vs SS-31
- GLP-1 Family Research: From Semaglutide to Tri-Agonists
- Healing Peptides: BPC-157 & TB-500 Overview
Frequently Asked Questions
- How do I choose between “metabolic” and “obesity” peptide categories?
- “Metabolic” emphasizes mitochondrial efficiency, nutrient partitioning, and insulin sensitivity. “Obesity” focuses on appetite and energy balance pathways (e.g., incretins, tri-agonists). Your study design determines fit.
- Do you provide Certificates of Analysis (COAs)?
- Yes. Every lot ships with a COA (≥99% purity) and is backed by our Quality & Integrity standards.
- Are these compounds for human use?
- No. All products are labeled and sold for research use only. They are not intended for human or animal consumption or any medical application.
- How should I store research peptides?
- Follow the guidance on each product page and COA. Many researchers use cold-chain storage and avoid repeated freeze-thaw cycles.