MOTS-C

MOTS-c is a mitochondrial-derived peptide consisting of 16 amino acids. It has been implicated in the regulation of metabolic homeostasis, insulin sensitivity, and adaptation to stress.

Discovered in 2015, MOTS-c represents a novel class of peptides encoded by mitochondrial DNA. Its identification has opened new avenues in understanding mitochondrial signaling and its impact on metabolism.

Potential Benefits & Mechanism of Action:

• Mitochondrial Connection: MOTS-C originates from within the mitochondria, the powerhouses of our cells responsible for energy production. Its role in cellular metabolism and communication positions it at the crossroads of various physiological processes.
  
  
• Metabolic Modulation: MOTS-C has shown promise in regulating metabolism by influencing insulin sensitivity and glucose utilization. Research suggests that it may enhance cellular responses to insulin, potentially contributing to improved blood sugar control.
  
  
• Energy Boosting Effects: MOTS-C's impact on mitochondrial function may result in increased cellular energy production. This could translate into improved overall energy levels and vitality.
  
  
• Physical Performance Enhancement: Studies have explored MOTS-C's potential to enhance physical performance and endurance. It may contribute to improved exercise capacity and recovery.
  
  
• Age-Related Benefits: MOTS-C's links to mitochondrial health and metabolism have sparked interest in its potential to counteract age-related decline. It may play a role in maintaining cellular health and resilience as we age.

MOTS-c functions by activating the AMPK pathway, a key regulator of energy balance, thereby enhancing metabolic flexibility and promoting healthy aging.

Preclinical studies in mice have demonstrated that MOTS-c administration improves insulin sensitivity, promotes weight loss, and enhances physical performance. Human studies are in early stages, with ongoing research exploring its therapeutic potential in metabolic disorders.