1 3

SS-31

SS-31

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$58.00
$58.00
Sale Sold out
Shipping calculated at checkout.
Quantity

SS-31 (Elamipretide) — Mitochondria-Targeted Tetrapeptide

SS-31 (Elamipretide) is a cell-permeable, aromatic-cationic tetrapeptide that concentrates in mitochondria and binds cardiolipin. In research, it’s used to explore mitochondrial bioenergetics, ROS control, membrane potential, and cell-stress adaptation.

Identifiers
  • CAS: 736992-21-5 
  • PubChem CID: 11764719 
  • Formula / MW: C32H49N9O5 · ≈ 639.8 Da 
  • Sequence: D-Arg-Dmt-Lys-Phe-NH2 (Dmt = 2,6-dimethyl-Tyr) 
  • Also known as: MTP-131, Bendavia, “SS-31” [oai_citation:4‡Wikipedia](https://en.wikipedia.org/wiki/Elamipretide?utm_source=chatgpt.com)
How It Works (Plain English)
  • SS-31 selectively associates with cardiolipin in the inner mitochondrial membrane, supporting cristae structure and electron-transport efficiency. 
  • It can reduce excessive ROS and help maintain membrane potential (Δψm) during stress, improving ATP generation. [oai_
  • Structure–activity work maps how aromatic–cationic features drive mitochondrial targeting and function. 
Why Researchers Use It
  • To model mitochondrial protection in oxidative or ischemic stress assays. 
  • To study bioenergetics (oxygen consumption, ATP, Δψm) in cell and tissue systems. 
  • To examine neuroinflammation/behavior links in LPS or toxin paradigms. 

Key Studies — What Was Tested, What Changed, Why It Matters

Cardiolipin interaction & membrane energetics
  • What was tested: Biophysical and cell studies of SS-31 binding to cardiolipin-rich membranes under calcium/oxidative stress.
  • What changed: Stabilized membrane interfaces, lower energetic cost under Ca2+ load, and improved ETC coupling.
  • Why it matters: Provides a mechanism for preserving Δψm and ATP output during stress exposures.
Oxidative stress & bioenergetics rescue
  • What was tested: SS-31 in mitochondrial injury models (cells/tissues) tracking ROS, ATP, and respiration.
  • What changed: Reduced ROS, restored oxygen-consumption rates, and better ATP preservation vs controls.
  • Why it matters: Demonstrates a practical tool for studying mitochondrial resilience across tissues.
Neuroinflammation & behavior (context)
  • What was tested: LPS-induced cognitive-impairment models with mitochondrial readouts.
  • What changed: Improved mitochondrial function and better memory performance in rodents.
  • Why it matters: Connects mitochondrial health with brain function in inflammatory stress models. 

Potential Research Applications

Bioenergetics

  • OCR/ECAR, ATP production, Δψm assays
  • Cardiolipin oxidation & cristae morphology

Stress & Injury Models

  • Ischemia-reperfusion, Ca2+ overload, oxidative injury
  • Muscle, heart, kidney, and neuron models

Neuro & Immunometabolism

  • LPS/toxin paradigms; behavior + mitochondrial endpoints
  • Mitophagy and quality-control pathways

Synergistic Peptides (for Study Design)

MOTS-c

  • Why pair: AMPK-centric energy signaling complements SS-31’s cardiolipin/ETC support.
  • Angle: Combine AMPK and mitochondrial-membrane metrics for integrated metabolism readouts.

GHK-Cu

  • Why pair: Tissue/ECM remodeling markers with mitochondrial stress endpoints.
  • Angle: Oxidative-stress gene panels + imaging of matrix and cristae organization.

9-ME-BC

  • Why pair: Dopaminergic & microglial assays benefit from mitochondrial support.
  • Angle: Pair neurite/microglia endpoints with Δψm and ATP metrics.

Design Notes

  • Report salt form (free base vs HCl) and vehicle; light/temperature can affect stability.
  • Include both acute (minutes–hours) and chronic (days) time points.
  • Use cardiolipin/ROS controls (e.g., peroxidation assays) for mechanism clarity.

Known Concerns (Context)

  • Handling: Protect from light; prepare fresh aliquots for reproducibility.
  • Model dependence: Outcomes vary by tissue and injury model; predefine primary endpoints.
  • General: Research use only; not for human consumption or therapeutic use.

Specifications & Handling

  • Form: Lyophilized powder (lot-coded)
  • Purity: ≥ 99% (HPLC/MS verified)
  • Storage: ≤ −20 °C; protect from light/moisture
  • In solution: Aliquot promptly; avoid repeat freeze–thaw
  • Additives: None unless specified per lot
  • Packaging: Tamper-evident; research-only labeling

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

SS-31 (Elamipretide) Peptide Research | Mitochondria-Targeted Tetrapeptide | Cardiolipin, ROS & ATP Studies

Keywords: SS-31 peptide, Elamipretide, MTP-131, cardiolipin binder, mitochondrial membrane potential, ROS, ATP, bioenergetics, Base Peptides.

View full details

Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
Keep Shopping