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KPV Tablets 500mcg

KPV Tablets 500mcg

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$150.00
$150.00
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KPV — α-MSH C-terminal Tripeptide (Lys-Pro-Val)

KPV is the minimal Lys-Pro-Val sequence from the C-terminus of α-melanocyte-stimulating hormone (α-MSH). It’s widely used to study innate immune signaling, epithelial barrier biology, and anti-inflammatory pathways in gut and skin models.

Identifiers
  • Core sequence: Lys–Pro–Val (KPV)
  • Common synonyms: α-MSH(11–13), ACTH(11–13) 
  • Representative CAS (free tripeptide): 67727-97-3 
  • Representative CAS (Ac-KPV-NH2): 112965-21-6 (acetylated, amidated research form) 
  • PubChem (example): CID 145457641 (tripeptide; form-dependent), CID 125672 (Ac-KPV-NH2) [
  • Notes: Molecular formula/MW vary by salt and end-group (free tripeptide often reported ~342.4 Da; Ac-amidated ~≈384–386 Da). 
How It Works (Plain English)
  • KPV is studied as a compact melanocortin fragment that preserves α-MSH’s anti-inflammatory signals in several models. 
  • In the gut, KPV can be transported by PepT1 (a di/tri-peptide transporter) into epithelial and immune cells—important for intestinal research. 
  • In skin/epithelium, KPV is used to probe cytokine balance and barrier support without relying on classic cAMP responses. 
Why Researchers Use It
  • To model anti-inflammatory peptide signaling in intestinal and cutaneous systems. 
  • To study epithelial barrier function, cytokines, and chemokines in response to stressors. 
  • To compare minimal motif activity against longer melanocortin fragments. 

Key Studies — What Was Tested, What Changed, Why It Matters

PepT1-mediated uptake & intestinal inflammation
  • What was tested: Whether KPV enters gut epithelial/immune cells via PepT1 and affects colitis severity in rodent models.
  • What changed: KPV uptake through PepT1 was demonstrated; oral KPV reduced DSS/TNBS colitis and pro-inflammatory cytokines. 
  • Why it matters: Supports use of KPV to study peptide-transporter biology and anti-inflammatory mechanisms in the intestine.
Melanocortin-fragment anti-inflammatory context
  • What was reviewed: α-MSH and its short C-terminal fragments (including KPV) retain antimicrobial/anti-inflammatory activity across models. 
  • Why it matters: Provides a mechanistic backdrop for using minimal sequences to parse immune pathways without full hormone complexity.
Keratinocyte signaling nuance
  • What was tested: cAMP signaling in human keratinocytes exposed to α-MSH, ACTH fragments, and KPV.
  • What changed: No cAMP elevation detected under several conditions, suggesting non-canonical pathways in these cells. 
  • Why it matters: Encourages broad endpoints (cytokines, NF-κB/MAPK, barrier metrics) when studying KPV in skin models.

Potential Research Applications

Gut & Barrier Biology

  • Intestinal epithelial transport (PepT1) & permeability assays
  • Cytokine/chemokine panels in DSS/TNBS paradigms

Skin & Epithelial Models

  • Inflammation and wound-closure assays
  • NF-κB/MAPK pathway readouts under stress

Comparative Melanocortins

  • KPV vs longer α-MSH fragments
  • Minimal-motif mapping and SAR

Synergistic Peptides (for Study Design)

LL-37

  • Why pair: Innate-defense peptide for epithelial repair and host-response studies alongside KPV.
  • Angle: Barrier integrity + cytokine balance in co-culture models.

BPC-157

  • Why pair: Tissue repair and microvascular endpoints complement KPV’s anti-inflammatory profile.
  • Angle: Migration (scratch) + inflammatory gene arrays.

Tα1 (Thymosin-α1)

  • Why pair: Tests innate → adaptive immune coordination with KPV’s epithelial focus.
  • Angle: Th1/Th2 panels + barrier metrics under challenge.

Design Notes

  • Specify form (free acid vs Ac-KPV-NH2 vs salt) in methods—readouts can differ.
  • Control media/serum lots and ionic strength; these shift cytokine baselines.
  • Include time-course and dose-response; transporter kinetics matter for PepT1 systems.

Known Concerns (Context)

  • Form-dependence: End-group/salt choice (e.g., acetylation/amide, acetate) can alter solubility and cell responses.
  • Assay variability: Outcomes vary by epithelial model, media conditions, and transporter expression; document conditions carefully.
  • General: Research use only; not for human consumption or therapeutic use.

Specifications & Handling

  • Form: Lyophilized powder (lot-coded)
  • Purity: ≥ 99% (HPLC/MS verified)
  • Storage: ≤ −20 °C; protect from light/moisture
  • In solution: Prepare fresh aliquots; avoid repeat freeze–thaw
  • Additives: None unless specified per lot
  • Packaging: Tamper-evident; research-only labeling

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

KPV Peptide Research | α-MSH(11–13) Tripeptide | Anti-inflammatory, Epithelial Barrier & PepT1 Transport Studies

Keywords: KPV peptide, Lys-Pro-Val, alpha-MSH fragment, ACTH(11-13), PepT1 transporter, anti-inflammatory tripeptide, intestinal epithelium, skin barrier, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
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