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Semax

Semax

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$50.00
$50.00
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Semax — ACTH(4-10)-PGP Heptapeptide (MEHFPGP)

Semax is a synthetic heptapeptide derived from the ACTH(4-10) fragment with a Pro-Gly-Pro (PGP) tail. It’s used in research to explore stress adaptation, neuroplasticity, cognition, and neuroimmune balance while avoiding sedative mechanisms.

Identifiers
  • CAS: 80714-61-0
  • PubChem CID: 9811102
  • Formula / MW: C37H51N9O10S · ~813.9 Da
  • Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
  • Origin: Analogue of ACTH(4-10) with a C-terminal PGP extension
How It Works (Plain English)
  • Semax modulates GABAergic and monoaminergic pathways tied to stress, focus, and mood.
  • It has been studied for effects on BDNF/TrkB signaling—key players in learning and synaptic plasticity.
  • It also shows neuroimmune effects (cytokine balance), linking inflammation with brain function in models of stress.
Why Researchers Use It
  • To probe stress resilience without sedative confounds.
  • To study memory, attention, and neuroplasticity markers (e.g., BDNF expression).
  • To examine neuroimmune cross-talk via cytokine profiling and gene-expression panels.

Key Studies — What Was Tested, What Changed, Why It Matters

Cognition & plasticity (BDNF-linked effects)
  • What was tested: Semax exposure in rodent learning/memory tasks with hippocampal assays.
  • What changed: Improved task performance with increases in BDNF/TrkB expression and antioxidant markers in cortex/hippocampus.
  • Why it matters: Supports Semax as a model for neuroplasticity—useful when studying adaptive learning and synaptic signaling.
Stress & anxiety-response paradigms
  • What was tested: Behavioral stress models (e.g., restraint/novelty) with neurotransmitter and cytokine readouts.
  • What changed: Reduced anxiety-like behavior, more balanced GABA/glutamate signaling, and shifts toward anti-inflammatory cytokine profiles.
  • Why it matters: Shows Semax can help parse neuroimmune mechanisms of stress adaptation without confounding sedation.
Ischemia/oxidative stress models
  • What was tested: Global/forebrain ischemia models and oxidative-stress assays.
  • What changed: Signals consistent with neuroprotection (e.g., lipid-peroxidation reduction, NO modulation) and better behavioral recovery.
  • Why it matters: Provides a basis for studying injury-response cascades and antioxidant gene programs.

Potential Research Applications

Neuroscience & Behavior

  • BDNF/TrkB and synaptic-plasticity assays
  • Attention, memory, and stress-behavior tasks

Neuroimmune Cross-Talk

  • Cytokine panels (Th1/Th2 balance)
  • Glia markers and neuroinflammation

Comparative Peptide Models

  • Selank / Semax side-by-side
  • Combination with trophic or antioxidant pathways

Synergistic Peptides (for Study Design)

Selank

  • Why pair: Neuroimmune-modulating heptapeptide; complements Semax on stress and focus pathways.
  • Angle: Dual-arm designs for behavior + cytokine/BDNF readouts.

GHK-Cu

  • Why pair: ECM and trophic signaling; useful in repair and antioxidant panels alongside Semax.
  • Angle: Gene-expression arrays for neurotrophic + matrix pathways.

MOTS-c

  • Why pair: AMPK-centric metabolic stress signaling may complement Semax’s CNS focus.
  • Angle: Fatigue-resilience, oxidative-stress, and behavior endpoints.

Design Notes

  • Standardize timing (short-acting peptide)—pair behavior with molecular sampling.
  • Include both central and peripheral markers (brain + serum cytokines).
  • Protect from oxidation/light; prepare fresh aliquots for reproducibility.

Known Concerns (Context)

  • Stability: Solution-sensitive; handle cold and minimize light exposure.
  • Model dependence: Behavioral outcomes vary with environment—tighten protocols (habituation, time-of-day, handling).
  • General: Research use only; not for human consumption or therapeutic use.

Follow institutional SOPs for neurobehavioral studies and peptide handling.

Specifications & Handling

  • Form: Lyophilized powder (lot-coded)
  • Purity: ≥ 99% (HPLC/MS; lot-verified)
  • Storage: ≤ −20 °C; protect from light/moisture
  • In solution: Aliquot promptly; avoid repeat freeze–thaw
  • Additives: None unless specified per lot
  • Packaging: Tamper-evident; research-only labeling

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

Semax Peptide Research | ACTH(4-10)-PGP Heptapeptide | BDNF/TrkB, Stress & Neuroimmune Studies

Keywords: Semax peptide, ACTH(4-10) analogue, MEHFPGP sequence, BDNF, TrkB, neuroplasticity, anxiety stress models, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
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