SEMA

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

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Semaglutide — GLP-1 Receptor Analogue for Metabolic Research

Semaglutide is a long-acting peptide analogue of glucagon-like peptide-1 (GLP-1), a natural hormone that helps regulate appetite, glucose levels, and energy balance. In research, it’s used to study insulin secretion, satiety pathways, and body-composition shifts in metabolic and endocrine models.

Identifiers

CAS: 910463-68-2
PubChem CID: 56843331
Formula / MW: C₁₈₇H₂₉₁N₄₅O₅₉ · ≈ 4113 Da
Sequence: Modified GLP-1(7–37) analogue with substitutions for stability and albumin binding

How It Works (Plain English)

Semaglutide mimics the body’s own GLP-1 hormone, which is released after meals.
It binds to GLP-1 receptors in the pancreas and brain to support insulin release, slower gastric emptying, and a natural sense of fullness.
In research models, this helps explore metabolic efficiency, appetite signaling, and glucose control mechanisms.

Why Researchers Use It

To study GLP-1 receptor signaling in glucose and lipid metabolism.
To evaluate appetite and energy-expenditure pathways.
To model long-acting incretin analogues and their tissue effects.

Key Studies — What Was Tested, What Changed, Why It Matters

Glucose regulation and insulin response models

What was tested: Semaglutide’s impact on fasting and post-meal glucose in both animal and human studies.
What changed: Clear improvements in insulin sensitivity and glucose tolerance with fewer glucose spikes after feeding.
Why it matters: Demonstrates how GLP-1 receptor activation helps fine-tune insulin secretion and reduce metabolic stress in pancreatic-cell research.

Appetite and energy-intake studies

What was tested: Central and peripheral GLP-1 receptor activation related to food intake and satiety signaling.
What changed: Research consistently shows reduced caloric intake and delayed gastric emptying, with activation of appetite-regulation centers in the brainstem and hypothalamus.
Why it matters: Provides a model to study the brain-gut axis and its role in body-weight regulation.

Body-composition and lipid studies

What was tested: Effects of prolonged GLP-1 activation on fat and lean-mass distribution.
What changed: Consistent findings of visceral fat reduction and improved lipid markers (triglycerides and cholesterol fractions) over time.
Why it matters: Offers insight into how incretin pathways influence long-term metabolic remodeling beyond glucose alone.

Potential Research Applications

Metabolic Function

Glucose tolerance and insulin-release studies
Pancreatic β-cell and incretin assays

Appetite & Satiety Models

Neuro-endocrine signaling and food-intake research
Gastric-emptying kinetics and brain-gut axis studies

Body-Composition Research

Fat-mass, lean-mass, and lipid-panel tracking
Visceral adiposity imaging and metabolic flexibility

Synergistic Peptides (for Study Design)

Tirzepatide

Why pair: Dual GLP-1 and GIP receptor agonist, allowing comparison between single-pathway vs dual-pathway incretin signaling.
Angle: Combined analysis of insulin sensitivity, appetite control, and adipose signaling.

AOD-9604

Why pair: Fragment of GH used in studies of fat metabolism and energy mobilization.
Angle: Pairing with semaglutide offers insight into adipose and mitochondrial activity under dual stimulation.

CJC-1295 (with DAC)

Why pair: Explores metabolic and hormonal cross-talk between GH/IGF-1 and GLP-1 axes.
Angle: Long-term metabolic experiments tracking lipid and glucose markers.

Design Notes

Clearly separate single vs combination peptide arms.
Track food-intake timing, fasting glucose, and body-composition data points.
Document all formulation details—GLP-1 analogues are sensitive to pH and light.

Known Concerns (Context)

Stability: Semaglutide is temperature- and light-sensitive—store frozen and handle gently.
Model design: Appetite and glucose markers can fluctuate with stress and feeding schedules; control environmental variables tightly.
General: For research use only; not for therapeutic or human consumption purposes.

Follow institutional SOPs for metabolic and endocrinology peptide handling.

Specifications & Handling

Form: Lyophilized powder (lot-coded)
Purity: ≥ 99 % (HPLC/MS verified)
Storage: ≤ −20 °C; protect from light/moisture

In solution: Aliquot; avoid repeat freeze–thaw
Additives: None unless specified per lot
Packaging: Tamper-evident; research-only labeling

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

Semaglutide Peptide Research | GLP-1 Receptor Analogue | Metabolic, Appetite & Glucose Studies

Keywords: Semaglutide peptide, GLP-1 receptor, incretin analogue, appetite regulation, glucose control, metabolic research, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.

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