Selank

Selank

Primary Function: Anxiolytic and nootropic peptide
Research Use: Anxiety, stress response, memory support
Molecular Formula: C33H57N11O9
CAS Number: 129954-34-3
Synonyms: TP-7

Description:
Selank is a synthetic heptapeptide derived from tuftsin, developed for its anxiolytic, antidepressant, and cognitive-enhancing properties. It is frequently studied for its potential to modulate GABAergic and monoamine neurotransmitter systems without the sedative effects of benzodiazepines.

Mechanism of Action:

• Regulates expression of GABA and serotonin receptors
• Modulates neurotrophic factors like BDNF
• Supports stress resilience and neuroplasticity

Key Research Areas:

• Anxiety and social phobia models
• Cognitive function and memory formation
• PTSD and mood regulation research
• Immune modulation in chronic stress

History of Discovery:
Selank was developed in Russia by the Institute of Molecular Genetics. The peptide is based on tuftsin, a naturally occurring peptide involved in immune response modulation. It was designed to enhance the body’s stress resilience while improving cognitive function.

Case Studies:

1. Anxiolytic Effects in Social Phobia (2005, J Neuropsychiatry Clin Neurosci): In a clinical trial, Selank significantly reduced symptoms of social anxiety and improved mood in patients with social phobia. [Ref: J Neuropsychiatry Clin Neurosci. 2005;17(4):431–437.]
2. Cognitive Enhancement in Memory Impairment (2007, Neurochem Res): A study on elderly patients with mild cognitive impairment found improved short-term memory and focus with Selank administration. [Neurochem Res. 2007;32(9):1651–1657.]
3. Stress Resilience and Mood Stabilization (2010, Clin Neuropharmacol): Selank demonstrated a reduction in depressive symptoms and improved stress resilience in patients with chronic stress disorders. [Clin Neuropharmacol. 2010;33(4):178–182.]

Packaging Information:

• Form: Lyophilized powder or nasal solution
• Purity: ≥ 99%
• Storage: Store at -20°C in a dry, dark environment
• For research use only. Not for human or veterinary use.