BPC-157

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$55.00

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Product Option 3ml Vial - 5mg 3ml Vial - 10mg 15ml Nasal Spray - 30mg 60 Oral Capsules - 500mcg 120 Oral Capsules - 500mcg

BPC-157 — Research-Grade Pentadecapeptide

BPC-157 is a 15-amino-acid fragment (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) originally derived from a protective protein found in gastric juice. In research settings, it’s used to explore cell-signaling involved in tissue resilience, local blood-flow changes, and gut-barrier integrity.

Identifiers

CAS: 137525-51-0
PubChem CID: 9941957
Formula / MW: C₆₂H₉₈N₁₆O₂₂ · ≈1,419.5 Da
Sequence: pentadecapeptide (15 aa), shown above

How It’s Thought to Work

Originally studied as a stomach-derived protective signal (“body protection compound”).
Preclinical work suggests it may influence angiogenic markers (tiny blood-vessel growth/repair) and cell-migration signals important for tissue maintenance.
Frequently used in models that probe gut epithelial barrier behavior and local microcirculation.

Why Researchers Use It

To observe changes in cell signaling related to tissue upkeep and stress response.
To measure barrier function and tight-junction proteins in gut/epithelial models.
To explore local microvascular dynamics (blood flow markers) in preclinical assays.

Key Studies — What Was Tested, What Changed, Why It Matters

Gut & barrier models (cell and animal)

What was tested: Cell-culture and animal models where the intestinal lining or other epithelial layers are challenged.
What changed: Signals consistent with better barrier integrity (e.g., tight-junction behavior) and changes in local inflammatory markers have been reported.
Why it matters: These models help labs understand how peptide cues might influence the “seal” between cells—important for nutrient transport and defense in many tissues.

Tissue-maintenance & microcirculation models

What was tested: Assays that track cell migration, matrix remodeling, and small-vessel behavior after a standardized stressor.
What changed: Preclinical reports describe shifts in markers related to angiogenesis and matrix balance—signals that often precede visible tissue changes.
Why it matters: Understanding these early markers helps researchers design smarter protocols before moving to larger animal work.

Nerves, tendons, and connective-tissue paradigms

What was tested: Targeted models of tendon or nerve stress where labs watch how cells organize and communicate after an insult.
What changed: Some studies report changes in axon-related or tenocyte markers and local perfusion signals; results depend on model and timing.
Why it matters: These data help teams decide when to measure outcomes (early molecular markers vs later functional readouts).

Potential Research Applications

Gut & Epithelial Biology

Tight-junction proteins (e.g., occludin/claudins)
Barrier-leak assays and permeability tests

Microvascular & Matrix Signaling

Angiogenesis markers and microcirculation imaging
Extracellular-matrix balance and cell migration

Connective-Tissue Models

Tenocyte behavior and collagen organization
Nerve-associated molecular markers (model-dependent)

Synergistic Peptides (for Study Design)

TB-500 / Thymosin-β4 fragments

Why pair: Often studied for cell migration and matrix-remodeling cues complementary to BPC-157’s reported signals.
Angle: Parallel or factorial designs to assess additive effects on early tissue-signaling markers.

GHK-Cu (Copper Tripeptide)

Why pair: Used in skin/ECM research; can complement BPC-157 in extracellular-matrix and microenvironment assays.
Angle: Compare matrix-gene expression panels and imaging endpoints.

KPV (α-MSH fragment) (if in catalog)

Why pair: Frequently used in epithelial models for inflammatory-signal moderation.
Angle: Permeability + cytokine panels along with barrier-function readouts.

Design Notes

Keep arms clearly separated (BPC-only vs combo) and pre-register endpoints.
Capture timing: early molecular signals can precede visible effects.
Document lot numbers, pH/vehicle, and application route for reproducibility.

Known Concerns (Context)

Heterogeneity: Protocols and models vary widely across the literature; reproduce with tight controls.
Interpretation: Many findings are from preclinical work; translate cautiously and avoid consumer-style claims.
Documentation: Record handling (temperature, light, vehicle) and sampling times precisely—results can be timing-sensitive.

Follow your institution’s SOPs and oversight (IRB/IBC) for handling and design.

Specifications & Handling

Form: Lyophilized powder (lot-coded)
Purity: ≥ 99% (HPLC/MS; lot-verified)
Storage: ≤ −20 °C; protect from light/moisture

In solution: Prepare aliquots promptly; avoid repeat freeze–thaw
Additives: None unless specified per lot
Packaging: Tamper-evident; research-only labeling

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

BPC-157 Peptide Research | Pentadecapeptide | Gut Barrier, Microvascular & Matrix Signaling Models

Keywords: BPC-157 peptide, pentadecapeptide, gut barrier function, angiogenesis markers, extracellular matrix, microcirculation, Base Peptides research grade.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.

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