BPC-157

BPC-157 (Body Protection Compound-157)

Primary Function: Tissue regeneration, gut repair, vascular healing
Research Use: Tendon and ligament recovery, intestinal integrity, inflammation modulation
Molecular Formula: C62H98N16O22
CAS Number: 137525-51-0
Synonyms: PL 14736, Pentadecapeptide BPC, Body Protection Compound

Description:
BPC-157 is a synthetic pentadecapeptide derived from a protective protein found in human gastric juice. It is extensively studied for its role in tissue regeneration, angiogenesis, and inflammation control, particularly in musculoskeletal injuries, gut disorders, and vascular dysfunction. BPC-157 has shown powerful effects in accelerating healing in soft tissues like tendons, ligaments, and intestines, while promoting cellular repair and protecting against oxidative damage.

Mechanism of Action:

• Stimulates angiogenesis via VEGF and nitric oxide pathways
• Enhances fibroblast migration and collagen deposition
• Supports epithelial and endothelial cell regeneration
• Modulates the immune system and suppresses pro-inflammatory cytokines

Key Research Areas:

• Tendon and ligament healing
• Inflammatory bowel disease and gut permeability
• Muscle regeneration and post-surgical recovery
• Neurological and vascular protection

History of Discovery:
BPC-157 was first developed by researchers in Zagreb, Croatia in the early 1990s. It was isolated as a fragment of a native gastric peptide involved in protecting and repairing the gastrointestinal tract. Ongoing studies have since uncovered broader applications in systemic tissue repair and neurovascular regeneration.

Case Studies:

1. Achilles Tendon Healing (2011, J Orthop Res): Rats treated with BPC-157 showed improved collagen organization and faster recovery of tendon strength. [J Orthop Res. 2011;29(3):437–444.]
2. Gastrointestinal Barrier Protection (2009, Curr Pharm Des): BPC-157 prevented NSAID-induced gut injury and maintained epithelial integrity in rodent models. [Curr Pharm Des. 2009;15(7):778–789.]
3. Vascular Recovery Post-Trauma (2010, J Physiol Pharmacol): BPC-157 stimulated blood vessel regeneration and reduced clot formation following vascular injury. [J Physiol Pharmacol. 2010;61(5):565–572.]

Packaging Information:

• Form: Lyophilized powder
• Purity: ≥ 99%
• Storage: Store at -20°C in a dry, dark environment
• For research use only. Not for human or veterinary use.