SNAP 8 - 10mg

SNAP-8

Primary Function: Muscle contraction modulation, wrinkle reduction, anti-aging support
Research Use: Cosmetic peptide research, neuromuscular signaling, dermal relaxation
Molecular Formula: C55H90N14O15S
CAS Number: 868844-74-0
Synonyms: Acetyl Octapeptide-3, SNAP-8 Solution

Description:
SNAP-8 is a cosmetic research peptide designed to reduce dynamic facial wrinkles by inhibiting muscle contraction pathways. It is an octapeptide derived from SNAP-25, a protein involved in the SNARE complex, which regulates neurotransmitter release and facial muscle tension. Often referred to as a "Botox alternative" in topical peptide research, SNAP-8 has been shown to soften expression lines and reduce the depth of wrinkles in cosmetic studies.

Mechanism of Action:

• Competes with SNAP-25 for binding to the SNARE complex
• Inhibits vesicle release of acetylcholine at neuromuscular junctions
• Reduces facial muscle contractions responsible for expression lines
• Non-invasive peptide-based alternative to neurotoxins like Botulinum

Key Research Areas:

• Topical anti-aging formulations
• Wrinkle depth reduction and facial line smoothing
• Neuromuscular inhibition models
• Skin elasticity and dermal relaxation studies

History of Discovery:
SNAP-8 was developed by Lipotec (now part of Lubrizol) as a second-generation version of Argireline (Acetyl Hexapeptide-8), with improved efficacy and lower cytotoxicity. It was introduced into cosmetic research as a topical peptide capable of mimicking the effects of Botox through non-invasive pathways.

Case Studies:

1. Wrinkle Depth Reduction (2005, Lipotec Internal Study): A 28-day clinical trial using 10% SNAP-8 topical solution showed up to 63% reduction in wrinkle depth, particularly in forehead and periocular regions.
2. Synergistic Use in Peptide Creams (2011, Cosmet Chem J): SNAP-8 combined with hyaluronic acid and peptides like Matrixyl increased hydration and expression line smoothing effects.
3. Safety and Efficacy Profile (2013, Int J Cosmet Sci): Demonstrated low irritation potential and effective dose-response curve for topical cosmetic applications. [Int J Cosmet Sci. 2013;35(6):567–574.]

Packaging Information:

• Form: Lyophilized powder or pre-diluted solution
• Purity: ≥ 99%
• For research use only. Not for human or veterinary use.