SNAP 8 - 10mg
SNAP 8 - 10mg
Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.
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SNAP-8 (Acetyl Octapeptide-3) — Cosmeceutical Peptide for Dynamic Wrinkle Reduction
SNAP-8 is a synthetic octapeptide developed to target expression lines by modulating the SNARE complex and reducing neurotransmitter-mediated muscle contraction. While many peptides target collagen or structural skin support, SNAP-8 is especially relevant in research on dynamic wrinkles (e.g., forehead, crow’s feet) and non-invasive aesthetic modulation. [oai_citation:0‡HubMedEd](https://www.hubmeded.com/blog/snap-8-peptide-a-non-invasive-alternative-to-botox?utm_source=chatgpt.com)
Identifiers
- Synonyms: Acetyl Octapeptide-3, Acetyl Glutamyl Heptapeptide-1, SNAP-8
- Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ (octapeptide) [oai_citation:1‡Peptide Sciences](https://www.peptidesciences.com/snap-8-200mg-topical?utm_source=chatgpt.com)
- Molecular weight approx: ~1,075 Da [oai_citation:2‡Peptide Sciences](https://www.peptidesciences.com/snap-8-200mg-topical?utm_source=chatgpt.com)
- Class: Cosmeceutical aesthetic peptide; neuromodulator-mimetic
How It Works (Plain English)
- Competes with the SNAP-25 protein for participation in the SNARE complex, which is crucial for vesicle fusion and acetylcholine release at neuromuscular junctions. [oai_citation:3‡Minutehack](https://minutehack.com/news/everything-you-need-to-know-about-snap-8-peptide?utm_source=chatgpt.com)
- By disrupting the normal SNARE assembly, it reduces the release of acetylcholine and thereby lessens contraction of the underlying facial muscles—resulting in a smoother skin appearance. [oai_citation:4‡HubMedEd](https://www.hubmeded.com/blog/snap-8-peptide-a-non-invasive-alternative-to-botox?utm_source=chatgpt.com)
- Unlike injected neuromodulators (e.g., botulinum toxin), SNAP-8 is typically used in topical/aesthetic research settings and integrated into formulations designed for skin delivery. [oai_citation:5‡lubrizol.com](https://www.lubrizol.com/personal-care/products/product-finder/products-data/snap-8-peptide-solution-c?utm_source=chatgpt.com)
Why Researchers Use It
- To quantify reduction in wrinkle depth and muscle-contraction–driven lines in human or ex-vivo skin models. [oai_citation:6‡HubMedEd](https://www.hubmeded.com/blog/snap-8-peptide-a-non-invasive-alternative-to-botox?utm_source=chatgpt.com)
- To test delivery technologies (microneedles, peptides + nano-carriers) for improved skin penetration. [oai_citation:7‡ResearchGate](https://www.researchgate.net/figure/Chemical-structures-of-SNAP-8-and-IS_fig1_343622597?utm_source=chatgpt.com)
- To evaluate the synergy of neuromodulator-mimetic peptides with structural skin peptides (e.g., collagen-stimulators) in aesthetic or anti-aging research. [oai_citation:8‡Minutehack](https://minutehack.com/news/everything-you-need-to-know-about-snap-8-peptide?utm_source=chatgpt.com)
Key Study Themes — What’s Typically Observed
Dynamic Wrinkle Depth & Expression Line Modulation
- What was tested: Topical formulations of SNAP-8 in human skin or ex-vivo skin, measuring wrinkle depth before/after and expression-driven contraction changes. [oai_citation:9‡HubMedEd](https://www.hubmeded.com/blog/snap-8-peptide-a-non-invasive-alternative-to-botox?utm_source=chatgpt.com)
- What changed: Significant reduction in wrinkle depth (reports up to ~50-60% in cosmetic literature) though data varies by formulation and concentration. [oai_citation:10‡HubMedEd](https://www.hubmeded.com/blog/snap-8-peptide-a-non-invasive-alternative-to-botox?utm_source=chatgpt.com)
- Why it matters: Supports use of peptide neuromodulators as non-invasive tools in aesthetic science and topical delivery research. [oai_citation:11‡Skin Perfection](https://www.naturalorganicskincare.com/products/snap-8-anti-wrinkle-peptide?srsltid=AfmBOor5Cb9htfzAryADYq-bE8zKR6klI1lZ6kmt3AJYG0MTSi6lQW5q&utm_source=chatgpt.com)
Potential Research Applications
Aesthetic Dermatology Models
- Formulation testing: comparing peptides + delivery systems for wrinkle reduction and expression-line mitigation.
Skin Penetration & Delivery Research
- Microneedle patches, liposomal/nano-carriers, optimized peptide skin delivery kinetics. [oai_citation:12‡ResearchGate](https://www.researchgate.net/figure/Chemical-structures-of-SNAP-8-and-IS_fig1_343622597?utm_source=chatgpt.com)
Combination Peptide Regimens
- Pairing neuromodulator-mimetic peptides (e.g., SNAP-8) with collagen synthesis boosters or antioxidant peptides to evaluate synergistic dermal outcomes. [oai_citation:13‡Minutehack](https://minutehack.com/news/everything-you-need-to-know-about-snap-8-peptide?utm_source=chatgpt.com)
Synergistic / Comparator Peptides & Agents
Argireline (Acetyl Hexapeptide-3)
- Why compare: Precursor neuromodulator peptide; SNAP-8 is a more potent derivative of Argireline. [oai_citation:14‡Minutehack](https://minutehack.com/news/everything-you-need-to-know-about-snap-8-peptide?utm_source=chatgpt.com)
Botulinum Toxin (in delivery research)
- Why compare: SNAP-8 mimics some aspects of neuromodulation without injection; good reference for delivery research.
Collagen-Stimulating Peptides (e.g., Palmitoyl Pentapeptide-4)
- Why pair: Combine expression-line reduction (SNAP-8) with structural skin support for comprehensive cosmetic research.
Known Concerns (Context)
- Skin penetration challenge: As a relatively large hydrophilic peptide (~1 kDa), delivery through the stratum corneum is a key constraint; many studies use enhanced delivery systems. [oai_citation:15‡ResearchGate](https://www.researchgate.net/figure/Chemical-structures-of-SNAP-8-and-IS_fig1_343622597?utm_source=chatgpt.com)
- Formulation-dependent results: The concentration, vehicle, stability, and peptide integrity all influence efficacy—many claims are anecdotal in consumer literature. [oai_citation:16‡HubMedEd](https://www.hubmeded.com/blog/snap-8-peptide-a-non-invasive-alternative-to-botox?utm_source=chatgpt.com)
- General research-use only: Much of the data comes from cosmetic/dermatologic research. This insert is intended for research specification; not human-use claims.
Specifications & Handling
- Form: Lyophilized peptide powder or aqueous solution (lot-coded) [oai_citation:17‡Peptide Sciences](https://www.peptidesciences.com/snap-8-200mg-topical?utm_source=chatgpt.com)
- Purity: Typically ≥ 98% (HPLC/MS) — verify supplier COA.
- Storage: Store cold, dark, dry; protect from moisture and prolonged high temperature. Many suppliers recommend 4 °C for solution form or ≤ –20 °C for long-term. [oai_citation:18‡Peptide Sciences](https://www.peptidesciences.com/snap-8-200mg-topical?utm_source=chatgpt.com)
- Solubility: Water-soluble; for research use dissolve per protocol and avoid repeated freeze-thaws.
- Labeling: Clearly marked “Research Use Only”; lot/SKU and expiry date; keep out of unauthorized use.
Regulatory & Use Notice
Sold for laboratory research use only. Not for human consumption, medical, or cosmetic therapeutic claims. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.
SNAP-8 Acetyl Octapeptide-3 Cosmetic Peptide | Expression Wrinkle Reduction | SNARE Complex Modulation
