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Pinealon

Pinealon

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$55.00
$55.00
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Pinealon (EDR) — Glu-Asp-Arg Tripeptide • Injectable Research Grade

Pinealon, also known as the EDR peptide, is a synthetic tripeptide (Glu-Asp-Arg) explored for neuroprotective and cell-stress biology. Studies in cells and animal models report modulation of oxidative stress markers, neuronal morphology, and gene-expression programs relevant to mitochondrial function and apoptosis.

Identifiers
  • Synonyms: EDR peptide; H-Glu-Asp-Arg-OH
  • Sequence: Glu-Asp-Arg (EDR)
  • CAS No.: 175175-23-2
  • PubChem CID: 10273502
  • Formula / MW (typ.): C15H26N6O8 • ~418.4 g·mol⁻¹
  • Class: Ultrashort peptide bioregulator (research)
How It Works (Plain English)
  • Redox & stress response: Designs show reduced ROS accumulation and improved cell viability under oxidative stress.
  • Neuronal structure: Reports of preserved dendritic spines and signaling linked to synaptic maintenance in disease models.
  • Gene programs: Transcriptomic work suggests effects on oxidative phosphorylation, apoptosis regulation, and cytoskeletal maintenance.
Why Researchers Use It
  • Probe neuroprotection and cellular resilience during hypoxia, oxidative stress, or developmental insult models.
  • Interrogate mitochondrial and apoptosis pathways via peptide-driven gene-expression changes.
  • Compare ultrashort peptides (e.g., Epitalon AEDG) for specificity of neural vs systemic effects.

Key Study Themes — What Was Tested, What Changed, Why It Matters

Oxidative Stress & Cell Viability
  • What was tested: Neuronal and immune cell models exposed to pro-oxidant stimuli ± Pinealon.
  • What changed: Lower ROS accumulation and higher viability vs. stress controls in a dose-dependent fashion.
  • Why it matters: Establishes EDR as a tool compound for redox biology and survival signaling screens.
Neurodevelopmental & Behavioral Readouts
  • What was tested: Rodent developmental models (e.g., prenatal ethanol exposure) with cognitive endpoints.
  • What changed: Improved offspring cognitive performance and neuronal morphology in select paradigms.
  • Why it matters: Positions Pinealon for studies of synaptic plasticity and learning under stressors.
Gene-Expression / Mitochondrial Programs
  • What was tested: In vitro transcriptomics after EDR exposure.
  • What changed: Upregulation of OXPHOS related genes and regulators of apoptosis/cytoskeleton (model-dependent).
  • Why it matters: Suggests a mechanistic bridge between redox status and structural maintenance.

Potential Research Applications

Neuroprotection & Plasticity

  • Hypoxia/ischemia, excitotoxicity, neurodegeneration models; dendritic spine analyses.

Mitochondrial & Redox Biology

  • ROS/RNS panels, antioxidant defenses, OXPHOS gene sets, apoptosis markers.

Developmental Stress Models

  • Prenatal toxin exposure, behavior tasks, synaptic maturation readouts.

Synergistic / Comparator Peptides

Epitalon (AEDG)

  • Why compare: Another ultrashort peptide; contrast systemic vs neural emphasis.

Semax / Selank

  • Why pair: Cognitive/anti-stress research paradigms alongside redox-focused EDR.

Cerebrolysin (mixture)

  • Why compare: Broad neurotrophic signatures vs focused tripeptide probes.

What’s in the Vial (Editable)

Active Per Vial Grade / Purity
Pinealon (Glu-Asp-Arg) 20 mg (set per SKU) Research-grade, ≥ 98–99% (HPLC/MS)
Appearance White to off-white lyophilized powder
Solubility Water-soluble; prepare fresh sterile solution for lab use

Specifications & Handling

  • Form: Lyophilized peptide powder (lot-coded)
  • Storage: ≤ −20 °C long-term; protect from light/moisture
  • Stability: Avoid repeated freeze–thaw; record pH and time-to-assay after reconstitution
  • Labeling: “Research Use Only”; CAS/lot/SKU and expiration clearly displayed
  • QC (per lot): HPLC/MS identity & purity; residual solvents; bioburden/endotoxin if sterile-filtered

Known Concerns (Context)

  • Evidence base: Much of the literature originates from Russian research groups; limited randomized human data.
  • Assay variability: Outcomes are model- and dose-dependent; standardize redox and culture conditions.
  • General: For laboratory research use only; not for human consumption or therapeutic/veterinary use.

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

Pinealon (EDR) Research Peptide | Glu-Asp-Arg Tripeptide | Neuroprotection, Oxidative Stress & Gene-Expression Studies

Keywords: Pinealon, EDR peptide, Glu-Asp-Arg, ultrashort peptide bioregulator, neuroprotective peptide, oxidative stress, OXPHOS genes, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
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