Pinealon

Pinealon

Primary Function: Cognitive support, neuroprotection, anti-aging at the neural level
Research Use: Brain aging, memory loss, oxidative stress, neurodegenerative conditions
Molecular Formula: C14H26N6O4
CAS Number: 61477-96-1
Synonyms: Pinealon dipeptide, Glu-Asp-Arg, Tripeptide AED

Description:
Pinealon is a short synthetic tripeptide (Glu-Asp-Arg) originally isolated from the pineal gland. It is studied for its ability to cross the blood-brain barrier and promote neurogenesis, mitochondrial function, and cognitive resilience. Pinealon is of growing interest in models of age-related cognitive decline, oxidative damage, and neurodegenerative diseases, where it has shown potential to restore neuronal plasticity and reduce inflammatory stress.

Mechanism of Action:

• Enhances neuronal protein synthesis and mitochondrial ATP production
• Reduces lipid peroxidation and reactive oxygen species in brain tissue
• Promotes neuronal survival under hypoxic and ischemic conditions
• Modulates gene expression associated with cellular longevity and repair

Key Research Areas:

• Brain aging and age-related memory loss
• Post-stroke neuroprotection
• Alzheimer’s and cognitive decline models
• Brain mitochondrial dysfunction

History of Discovery:
Pinealon was developed by Russian researchers at the St. Petersburg Institute of Bioregulation and Gerontology, as part of a broader initiative to create neuroprotective bioregulators. Derived from pineal extracts, the Glu-Asp-Arg tripeptide was found to modulate gene expression in brain tissue and has since been investigated in both animal and human models for its cognitive-enhancing effects.

Case Studies:

1. Memory Retention in Aging Rats (2003, Bull Exp Biol Med): Pinealon administration improved memory and learning behavior in aged rats exposed to chronic hypoxia. [Bull Exp Biol Med. 2003;136(5):474–476.]
2. Oxidative Stress Reduction (2010, Adv Gerontol): Demonstrated a 40% decrease in malondialdehyde levels in brain tissue following Pinealon treatment in senescent mice. [Adv Gerontol. 2010;23(1):96–102.]
3. Protective Effects After Cerebral Ischemia (2008, Biogerontology): Pinealon reduced infarct size and preserved mitochondrial enzyme function in ischemia-reperfusion injury models. [Biogerontology. 2008;9(5):307–313.]

Packaging Information:

• Form: Lyophilized powder
• Purity: ≥ 99%
• For research use only. Not for human or veterinary use.