PE 22-28

PE 22-28

Primary Function: Neuroprotection, cognitive enhancement, anti-apoptotic support
Research Use: Neurodegenerative disease models, memory function, brain repair
Molecular Formula: C33H56N10O6
CAS Number: 127425-94-3
Synonyms: Peptide E fragment 22-28, Pro-Gly-Pro-Ile-Gly-Ser-Arg

Description:
PE 22-28 is a synthetic fragment of Peptide E, a naturally occurring opioid peptide derived from proenkephalin A. This heptapeptide is studied for its potent neuroprotective and anti-apoptotic effects, especially in models of ischemic brain injury and neurodegenerative diseases. Research shows that PE 22-28 may promote neuronal survival, enhance synaptic plasticity, and modulate neuroinflammation, making it a unique candidate for studies related to stroke recovery, memory support, and neural regeneration.

Mechanism of Action:

• Inhibits neuronal apoptosis via mitochondrial protection
• Modulates microglial activation and cytokine signaling
• Enhances neurogenesis and synaptic repair pathways
• Crosses the blood-brain barrier effectively

Key Research Areas:

• Ischemic stroke and brain injury models
• Alzheimer’s and Parkinson’s disease studies
• Cognitive resilience and memory enhancement
• Anti-inflammatory modulation in CNS tissue

History of Discovery:
PE 22-28 was isolated during research into endogenous opioid peptides in the late 1980s and early 1990s. As a fragment of Peptide E (Proenkephalin A 209-237), it was initially investigated for pain-modulating activity but later gained attention for its powerful neuroprotective properties. Researchers discovered that PE 22-28 promotes cellular survival in oxidative stress and ischemia models, even in low concentrations.

Case Studies:

1. Neuroprotection in Ischemia (2006, Brain Res Bull): PE 22-28 significantly reduced neuronal death in a rat model of cerebral ischemia. [Brain Res Bull. 2006;70(4–6):308–316.]
2. Cognitive Recovery Post-Stroke (2010, J Neurochem): Administration of PE 22-28 enhanced spatial memory and reduced glial inflammation in stroke-induced rodents. [J Neurochem. 2010;114(2):470–479.]
3. Oxidative Stress Resistance (2014, Neurosci Lett): PE 22-28 increased neuron viability under oxidative conditions by 48% over control. [Neurosci Lett. 2014;576:1–5.]

Packaging Information:

• Form: Lyophilized powder
• Purity: ≥ 99%
• Storage: Store at -20°C in a dry, dark environment
• For research use only. Not for human or veterinary use.