NALT: N-Acetyl L-Tyrosine
NALT: N-Acetyl L-Tyrosine
Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.
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N-Acetyl L-Tyrosine (NALT) — Research-Grade
N-Acetyl L-Tyrosine (NALT) is an acetylated derivative of L-tyrosine studied for its physicochemical advantages (e.g., solubility/stability in certain media) and for its role as a **tyrosine precursor** in catecholamine synthesis pathways (L-DOPA → dopamine → norepinephrine/epinephrine) across cell, tissue, and neurocognitive research models.
- Chemical name: N-Acetyl-L-tyrosine
- Formula: C11H13NO4
- Molar mass: ~223.22 g/mol
- Appearance: White crystalline powder
- Purity: ≥ 99% (HPLC/MS; lot-verified)
- Solubility: Water soluble; improved vs L-tyrosine in many media
- • Acetylated tyrosine analogue with **enhanced handling** properties
- • De-acetylation can regenerate L-tyrosine in biological systems
- • Feeds catecholamine synthesis via tyrosine hydroxylase
- • Used in models probing stress, vigilance, and cognitive load
- Catecholamine pathway dynamics (L-DOPA/dopamine/NE)
- Attention & working-memory paradigms under stressors
- Fatigue, reaction time, and executive function models
- Media supplementation & formulation stability studies
Descriptions are for laboratory research design only; not for human use.
Background & Rationale
L-tyrosine is the immediate precursor to L-DOPA (via tyrosine hydroxylase), a rate-limiting step toward dopamine and downstream catecholamines. N-acetylation can improve handling/solubility characteristics; hydrolysis/de-acetylation can yield free L-tyrosine, making NALT a useful tool in protocols that compare delivery forms or study precursor flux in neurotransmitter pathways.
Mechanistic Highlights
Catecholamine Synthesis
- NALT → L-Tyrosine → L-DOPA (tyrosine hydroxylase) → Dopamine → NE/E
- Used to probe rate-limiting steps and cofactor effects (e.g., BH4)
Formulation/Media Utility
- Evaluated where L-tyrosine’s solubility is limiting
- Comparative stability/compatibility assessments in aqueous systems
Specifications & Handling
- Grade: Research-grade; ISO-audited manufacturing
- Additives: None unless specified per lot
- Storage (dry): 15–25 °C, airtight, low humidity; protect from light
- In-solution: Prepare fresh where possible; refrigerate aliquots and minimize freeze–thaw
- Compatibility: Validate with buffers, media, and co-actives per protocol
- pH: Near neutral in dilute aqueous solutions (adjust as needed)
- Packaging: Tamper-evident, lot-coded, purity-verified
Regulatory & Use Notice
Sold strictly for laboratory research. Not a dietary supplement, drug, or cosmetic. No human-use directions are provided. Buyer is responsible for appropriate handling and regulatory compliance.
