NAD Capsules - Nicotinamide Mononucleotide

Nicotinamide Mononucleotide (NMN) – NAD⁺ Precursor for Advanced Longevity & Cellular Energy Research

Overview

Nicotinamide Mononucleotide (NMN) is a biosynthetic precursor to NAD⁺ (Nicotinamide Adenine Dinucleotide), a coenzyme essential for mitochondrial function, cellular repair, and metabolic efficiency. As NAD⁺ levels decline with age, restoring this pathway has become a focal point in aging and metabolic research. NMN is actively being studied for its potential to promote healthy aging, metabolic resilience, cognitive support, and improved cellular energy production.

Mechanism of Action

NMN is converted intracellularly to NAD⁺ through the salvage pathway, primarily via nicotinamide phosphoribosyltransferase (NAMPT) and NMNAT enzymes. Elevated NAD⁺ levels subsequently activate key longevity-linked pathways, including:

• Sirtuins (SIRT1, SIRT3) – Regulate gene expression related to aging, inflammation, and metabolism
• PARPs (Poly ADP-ribose polymerases) – Involved in DNA damage repair
• AMPK – Enhances mitochondrial biogenesis and energy regulation

By restoring NAD⁺ availability, NMN helps support mitochondrial performance, genome stability, and cellular resilience against age-related decline.

Key Research Findings

✅ Supports Healthy Aging & Longevity

NMN supplementation has been shown to reverse NAD⁺ decline in aged subjects, restoring mitochondrial function and improving markers of biological age.

✅ Enhances Energy Metabolism

Improves glucose tolerance, ATP production, and insulin sensitivity in models of metabolic dysfunction.

✅ Neuroprotection & Cognitive Support

NMN elevates NAD⁺ in brain tissue, supporting memory, synaptic function, and neuroplasticity in preclinical studies.

✅ DNA Repair & Oxidative Stress Defense

Boosts PARP activity and sirtuin expression, contributing to genomic stability and reduced cellular stress.

Research Applications

NMN is currently under investigation in studies focused on:

• Longevity & anti-aging pathways
• NAD⁺ metabolism and salvage pathway regulation
• Neurodegenerative disease models (e.g., Alzheimer’s)
• Mitochondrial and metabolic disorders
• Insulin sensitivity & glucose metabolism
• Physical performance and fatigue resistance

Featured Clinical Research

📌 Yoshino et al., Science (2021)

“In overweight women with prediabetes, oral NMN supplementation significantly improved muscle insulin sensitivity and NAD⁺ bioavailability with no adverse effects.”

📌 Irie et al., Endocrine Journal (2020)

“NMN administration up to 500 mg/day was well tolerated in humans, with measurable increases in blood NAD⁺ observed within hours.”

Molecular Profile

• Compound β-Nicotinamide Mononucleotide
• CAS Number 1094-61-7
• Molecular Formula C₁₁H₁₅N₂O₈P
• Molecular Weight 334.22 g/mol
• Purity ≥99% (HPLC Verified)
• Appearance White crystalline powder
• Solubility Water soluble
• Storage Store at -20°C, protected from light a
• nd moisture