NAD Capsules - Nicotinamide Mononucleotide

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

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Volume 500mg - 60 Capsules 500mg - 120 Capsules

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NMN — β-Nicotinamide Mononucleotide (NAD⁺ Precursor)

NMN is a direct precursor to NAD⁺, a coenzyme central to cellular energy, DNA repair, and sirtuin signaling. In research models, NMN supports redox balance, mitochondrial function, and metabolic health by replenishing intracellular NAD⁺ pools.

Identifiers

Synonyms: β-Nicotinamide mononucleotide; NMN; β-NMN
CAS No.: 1094-61-7
Formula / MW: C₁₁H₁₅N₂O₈P · ~334.22 g·mol⁻¹
Biochemical role: Intermediate in the NAD⁺ salvage pathway (via NAMPT → NMN → NAD⁺)

How It Works (Plain English)

Cells convert NMN into NAD⁺, which fuels enzymes that govern energy production (ETC/OXPHOS) and repair (PARPs, Sirtuins).
More NAD⁺ can translate into improved mitochondrial output and stress-response signaling in research settings.
Supports studies on metabolism, aging biology, neuroprotection, and exercise adaptation.

Why Researchers Use It

To probe NAD⁺ depletion in models of metabolic syndrome, high-fat diet, or aging.
To study DNA repair, oxidative stress, and cellular resilience via PARP/Sirtuin pathways.
To compare NAD⁺ precursors (NMN vs NR) and upstream regulators (NAMPT) head-to-head.

Key Study Themes — What’s Typically Observed

Metabolic & Mitochondrial Function

Endpoints: Tissue NAD⁺/NADH, mitochondrial respiration (OCR), ATP output, glucose tolerance, insulin signaling.
Findings (preclinical): ↑ NAD⁺ levels, improved glucose tolerance/insulin sensitivity, better mitochondrial metrics in diet-induced models.
Why it matters: Demonstrates how replenishing NAD⁺ can shift energy balance and metabolic signaling.

Aging Biology & Cellular Repair

Endpoints: DNA damage/repair markers, PARP activity, SIRT1/3 readouts, inflammatory cytokines.
Findings (preclinical): Improved repair markers and stress responses; context-dependent benefits in older models.
Why it matters: Links NAD⁺ availability with resilience pathways central to longevity research.

Potential Research Applications

Metabolic Health

Diet-induced obesity, insulin resistance, hepatic lipid metabolism

Cellular Energy & Exercise

Mitochondrial biogenesis (PGC-1α programs), endurance/adaptation models

Neuro & DNA Repair

Axonal energy, neuroinflammation markers, PARP-dependent repair

Synergistic / Comparator Compounds

5-Amino-1-MQ (NNMT inhibitor)

Why pair: Slows NAD⁺ drain (via NNMT) while NMN supplies substrate—dual support for NAD⁺ pools.

MOTS-c / SS-31

Why pair: Mitochondria-support peptides layered with NAD⁺ replenishment for bioenergetic studies.

NR (Nicotinamide Riboside)

Why compare: Parallel NAD⁺ precursor; useful for pathway mapping and delivery/formulation comparisons.

Design Notes

Document salt/form (e.g., chloride), particle size, moisture, and stability—NAD⁺ precursors are hygroscopic.
Include vehicle controls; track pH and storage time for solutions.

Known Concerns (Context)

Stability & hygroscopy: NMN can absorb moisture; potency depends on storage/handling.
Pathway complexity: NAD⁺ changes can affect many enzymes; off-target effects possible—use comprehensive panels.
General: For laboratory research use only; not for human consumption or therapeutic use.

Specifications & Handling

Form: Research-grade powder (lot-coded); specify salt (e.g., NMN chloride)
Purity: ≥ 99% (HPLC/MS verified)
Storage: Cool, dry, sealed; protect from light/humidity (consider desiccant)

In solution: Prepare fresh; record solvent, pH, and time-to-assay; minimize freeze–thaw cycles
Labeling: Tamper-evident; research-use-only; lot/SKU and expiration clearly displayed

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

NMN (β-Nicotinamide Mononucleotide) Research | NAD⁺ Precursor | Metabolism, Mitochondria & Longevity Studies

Keywords: NMN, beta-nicotinamide mononucleotide, NAD precursor, NAD salvage pathway, sirtuins, PARP, mitochondrial function, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.

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