Methylene Blue Face Cream 4oz
Methylene Blue Face Cream 4oz
Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.
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Methylene Blue Topical Cream0.01% — Advanced Antioxidant & Skin-Support Formula
This high-precision serum delivers **0.01% Methylene Blue (MB)** in a stabilized topical vehicle, formulated for visible skin-renewal support, protection against oxidative stress, and tone/texture enhancement. Recent research highlights MB’s mitochondrial-targeting antioxidant properties and potential skin-health benefits. [oai_citation:0‡PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC8699482/?utm_source=chatgpt.com)
Identifiers
- INCI/Name: Methylene Blue
- CAS No.: 61-73-4 (common) / see supplier COA
- Active Level: 0.01% (w/w) in the formulation — e.g., 0.10 g per 1 L of serum
- Class: Phenothiazine dye with strong redox/mitochondrial-modulating/antioxidant properties
How It Works (Plain English)
- MB supports mitochondrial respiratory chain efficiency and scavenges reactive oxygen species (ROS) — this can help skin cells maintain function under stress. [oai_citation:1‡PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC8699482/?utm_source=chatgpt.com)
- In skin models, MB has demonstrated enhanced fibroblast proliferation, elevated extracellular-matrix (collagen / elastin) markers, and improved appearance of skin thickness/tone. [oai_citation:2‡PubMed](https://pubmed.ncbi.nlm.nih.gov/28559565/?utm_source=chatgpt.com)
- At this low concentration (0.01%) the aim is to provide support rather than dramatic intervention — optimized for tolerance and everyday use rather than aggressive actives.
Why 0.01%?
- Emerging evidence suggests extremely low concentrations of MB (e.g., ~0.5 µM) are effective in skin models without risk of staining or irritation. [oai_citation:3‡Bluelene](https://bluelene.com/blogs/blog/the-right-methylene-blue-concentration-for-optimal-skin-health?utm_source=chatgpt.com)
- 0.01% (~100 ppm) is aligned with safe topical use margins and helps minimize the blue-tint risk while still delivering functional benefit.
Highlighted Research & Skin-Support Themes
Anti-aging & Fibroblast Support
- Study: Skin fibroblasts from progeria patients treated with MB showed improved proliferation, reduced markers of senescence, increased collagen/elastin gene expression. [oai_citation:4‡PubMed](https://pubmed.ncbi.nlm.nih.gov/28559565/?utm_source=chatgpt.com)
- Interpretation: MB may support dermal matrix health and visible skin vitality rather than just surface hydration — a potential differentiator.
Topical Use & Delivery Considerations
- Methylene Blue nano-emulsion in wound-healing models used ~0.1 mg/mL (0.01% ≈ 0.1 mg/mL) to support angiogenesis and healing in diabetic mice. [oai_citation:5‡PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC10496548/?utm_source=chatgpt.com)
- In skincare branding context, some companies cite effective concentrations as low as 0.5 µM (~0.000016%); hence 0.01% is conservative and well above the minimal effective threshold. [oai_citation:6‡Bluelene](https://bluelene.com/blogs/blog/the-right-methylene-blue-concentration-for-optimal-skin-health?utm_source=chatgpt.com)
Formula Snapshot (Editable)
| Active | Level | Function |
|---|---|---|
| Methylene Blue | 0.01% | Cellular antioxidant, mitochondrial support, visible tone/texture enhancement |
How to Use
- Apply 2–3 drops (or pump) to clean, dry face **at night** (or PM/AM as directed by your regimen).
- Follow with a light moisturizer if desired; if layering other actives (retinol, acids), alternate nights or consult formulation protocol.
- Patch-testing recommended. MB is a potent dye; even at low concentrations some tinting or sensitivity may occur.
Always store away from direct sunlight and air to maintain integrity.
Formulation & Compatibility Notes
Packaging & Stability
- MB is light-sensitive and may oxidize/discolour; use opaque or air-less packaging and keep cool/dark.
- Ideal vehicle: aqueous/emulsion serum with chelator-free or low-chelating environment (to not bind copper/iron unintendedly). Avoid high levels of strong reducing/oxidizing agents unless tested.
Compatible Actives
- Barrier-supporting hydrators (HA, ceramides), antioxidants (vitamin C, glutathione) are good pairings.
- Be cautious with strong photosensitisers or heavy actives (e.g., high-dose acids, aggressive exfoliants) in same regimen unless tolerance confirmed.
Use Caution With
- MB has MAO-inhibitor activity in systemic use; while topical use at low concentration is far more benign, avoid layering other MAO-active agents and consult formulation safety. [oai_citation:7‡Harvard Health](https://www.health.harvard.edu/diseases-and-conditions/what-to-know-about-methylene-blue?utm_source=chatgpt.com)
- Because MB is a dye, higher concentrations may stain skin/clothing; limit to well-controlled formula. [oai_citation:8‡Bluelene](https://bluelene.com/blogs/blog/the-right-methylene-blue-concentration-for-optimal-skin-health?utm_source=chatgpt.com)
Specifications
| Texture | Lightweight serum, mildly tinted blue-hue (normal) |
|---|---|
| Skin Types | Most types; if very sensitive or using other actives, introduce slowly. |
| Packaging | Opaque or air-less dropper/pump to protect from light/air. |
| Free-From | Fragrance-free, dye-free (apart from inherent MB hue), minimalist supporting ingredients (customise as needed) |
Synergistic / Comparator Actives
15% Vitamin C Serum
Morning antioxidant/brightening pairing; MB can serve night or alternate. Insightful layering for skin health.
GHK-Cu 4% Serum
Matrix support peptide; combine or alternate to build firm-looking, resilient skin.
Retinol 0.3-0.9% Serum
Renewal active; MB may help protect mitochondrial function alongside renewal protocols.
Precautions & Responsible Use
- Topical use only. Not for intravenous, internal or unregulated uses.
- Not intended for use around compromised skin (open wounds) unless specifically formulated for medical/dermal device use.
- If pregnant or nursing, consult your professional skin-care expert or dermatologist before use.
- Any visible staining of skin/clothing is normal at first – reduce frequency/volume if unacceptable.
Methylene Blue 0.01% Serum | Skin Antioxidant & Mitochondrial Support | Advanced Topical Treatment
