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Ipamorelin

Ipamorelin

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$40.00
$40.00
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Ipamorelin — Selective GHSR (Ghrelin Receptor) Agonist

Ipamorelin is a small pentapeptide that activates the ghrelin receptor (GHSR) in the pituitary. In research, it’s used to study growth-hormone (GH) release with a reputation for high receptor selectivity and a cleaner signal on non-GH hormones.

Identifiers
  • CAS: 170851-70-4
  • PubChem CID: 9831659
  • Formula / MW: C38H49N9O5 · ≈ 711.9 Da
  • Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2 (pentapeptide)
How It Works (Plain English)
  • Ipamorelin turns on the ghrelin receptor in the pituitary—one of the body’s switches for GH release.
  • That signal triggers a pulse of GH without strongly pushing other pituitary hormones in most models.
  • Researchers track GH and IGF-1 curves, receptor selectivity, and downstream metabolic markers.
Why Researchers Use It
  • To map GH pulse responses from GHSR activation.
  • To compare selectivity vs older secretagogues (e.g., GHRP-6).
  • To explore dual-pathway designs with GHRH analogues (combinational studies).

Key Studies — What Was Tested, What Changed, Why It Matters

Human volunteer studies — dose-dependent GH response
  • What was tested: Single and multiple doses of ipamorelin with serial GH/IGF-1 sampling.
  • What changed: Clear, dose-dependent GH pulses were observed. Importantly, many cohorts showed minimal changes in cortisol, ACTH, or prolactin compared with some older secretagogues.
  • Why it matters: This supports ipamorelin’s reputation as a more selective GHSR tool, making it useful when labs want to isolate GH-linked effects.
Comparative receptor selectivity vs legacy GHSR agonists
  • What was tested: Head-to-head comparisons with agents like GHRP-6/GHRP-2 in pituitary and clinical modeling.
  • What changed: Ipamorelin typically showed less spillover into non-GH pituitary hormones while maintaining a robust GH signal.
  • Why it matters: Cleaner selectivity helps researchers interpret downstream biomarkers without extra endocrine noise.
GH/IGF-1 dynamics and timing
  • What was tested: Time-course sampling to capture the onset, peak, and duration of GH pulses after ipamorelin.
  • What changed: Predictable GH peaks within a defined window, with IGF-1 changes following expected timelines.
  • Why it matters: Helps teams set sampling schedules and align ipamorelin with other interventions in combination studies.

Potential Research Applications

Endocrine Axis Mapping

  • GHSR-mediated GH pulses and timing
  • IGF-1 response curves and binding proteins

Comparative Secretagogue Studies

  • Ipamorelin vs GHRP-6/2 selectivity
  • Signal clarity in multi-hormone panels

Combination Designs

  • GHSR (ipamorelin) + GHRH analogue (e.g., CJC-1295)
  • Amplitude/frequency experiments on GH output

Synergistic Peptides (for Study Design)

CJC-1295 (with DAC)

  • Why pair: Hits the GHRH receptor; pairing with ipamorelin (GHSR) allows dual-pathway GH stimulation.
  • Angle: Map GH pulse amplitude vs frequency, and track IGF-1 exposure over longer windows.

Sermorelin / Mod GRF (1-29)

  • Why pair: Short-acting GHRH-type tools for precise pulse-timing experiments.
  • Angle: Compare brief vs sustained GH signaling when layered with ipamorelin.

Tesamorelin

  • Why pair: Physiologic GHRH analogue often used in VAT-focused research; helpful comparator in dual-pathway designs.
  • Angle: Endpoints can include IGF-1 curves, lipid panels, and imaging (where applicable).

Design Notes

  • Keep arms clearly separated: GHSR-only, GHRH-only, and combination.
  • Pre-define sampling times—GH peaks are time-sensitive.
  • Document vehicle, pH, and storage; small handling differences affect results.

Known Concerns (Context)

  • Sampling windows: GH pulses are brief—tight timing avoids missed peaks.
  • Assay noise: Multi-hormone panels can introduce confounders; ipamorelin is often chosen to reduce that noise.
  • General: Research use only; not a therapeutic compound.

Follow institutional SOPs and endocrine-study best practices for design and handling.

Specifications & Handling

  • Form: Lyophilized powder (lot-coded)
  • Purity: ≥ 99% (HPLC/MS; lot-verified)
  • Storage: ≤ −20 °C; protect from light/moisture
  • In solution: Aliquot promptly; avoid repeat freeze–thaw
  • Additives: None unless specified per lot
  • Packaging: Tamper-evident, research-only labeling

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

Ipamorelin Peptide Research | Selective GHSR Agonist | Growth Hormone Pulse Dynamics

Keywords: Ipamorelin peptide, ghrelin receptor agonist, GHSR, growth hormone secretagogue, GH pulses, IGF-1 kinetics, Base Peptides research grade.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
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