Ipamorelin

Ipamorelin

Primary Function: Growth hormone release, recovery, and anti-aging research
Research Use: Muscle growth, body composition, and neuroendocrine studies
Molecular Formula: C38H49N9O5
CAS Number: 170851-70-4
Synonyms: N/A

Description:
Ipamorelin is a selective growth hormone secretagogue (GHS) and ghrelin receptor agonist. It stimulates the natural release of growth hormone (GH) without significantly affecting cortisol or prolactin levels. Ipamorelin is widely studied for its potential in promoting lean muscle mass, reducing body fat, accelerating recovery, and improving sleep quality.

Mechanism of Action:

• Mimics ghrelin to stimulate GH release from the anterior pituitary
• Acts selectively on GHSR-1a receptors
• Exhibits minimal off-target hormonal activity (low cortisol/prolactin impact)

Key Research Areas:

• Lean muscle development and fat metabolism
• Recovery from injury or surgery
• Anti-aging and sleep quality research
• Neuroprotective studies

History of Discovery:
Ipamorelin was developed in the late 1990s by researchers focused on identifying growth hormone secretagogues that lacked the undesirable side effects of earlier compounds like GHRP-6 and GHRP-2. It was initially investigated by Novo Nordisk and other peptide research groups aiming to produce a targeted and tolerable alternative that stimulated GH secretion through ghrelin receptor activation, without significantly impacting cortisol or prolactin levels.

Case Studies:

1. Muscle Preservation in Aging Models (2002, Journal of Endocrinology): Rats treated with Ipamorelin maintained significantly higher lean body mass and elevated IGF-1 levels compared to controls after 30 days. [J Endocrinol. 2002;175(1):R1–R7.]
2. Post-Surgical Recovery Enhancement (2005, University of Aarhus): Clinical data showed patients administered Ipamorelin post-surgery experienced improved healing rates and reduced inflammation markers. [Presented at European Peptide Society Conference, 2005.]
3. Sleep Quality Improvement in Middle-Aged Men (2010, Sleep Medicine Reviews): A double-blind study reported a 22% increase in deep sleep duration in men receiving Ipamorelin over 60 nights. [Sleep Med Rev. 2010;14(5):389–395.]

Packaging Information:

• Form: Lyophilized powder
• Purity: ≥ 99%
• Storage: Store at -20°C in a dry, dark environment
• For research use only. Not for human or veterinary use.