GHRP-6

GHRP-6 (Growth Hormone Releasing Peptide-6)

Primary Function: Growth hormone release, appetite stimulation, recovery enhancement
Research Use: GH/IGF-1 modulation, muscle recovery, anti-aging, ghrelin pathway studies
Molecular Formula: C46H56N12O6
CAS Number: 87616-84-0
Synonyms: Growth Hormone Releasing Hexapeptide, GHRP6, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

Description:
GHRP-6 is a synthetic hexapeptide that stimulates endogenous growth hormone (GH) secretion through direct action on the ghrelin receptor (GHS-R1a). It significantly increases GH release while also mimicking the action of ghrelin to promote appetite and aid in metabolic regulation. GHRP-6 is studied for its potential applications in muscle growth, fat metabolism, injury recovery, and age-related hormonal decline.

Mechanism of Action:

• Binds to growth hormone secretagogue receptors (GHS-R1a)
• Increases pulsatile GH release from the pituitary gland
• Stimulates IGF-1 production in the liver
• Enhances appetite through ghrelin mimetic activity

Key Research Areas:

• Muscle growth and body composition
• GH deficiency and age-related decline
• Recovery from injury or surgery
• Appetite modulation and metabolic research

History of Discovery:
GHRP-6 was first developed in the 1980s by researchers investigating synthetic compounds capable of stimulating GH release independent of GHRH. It became one of the first peptides to effectively bind the ghrelin receptor, leading to the development of a new class of GH secretagogues with both endocrine and metabolic potential.

Case Studies:

1. GH and IGF-1 Elevation (1997, J Clin Endocrinol Metab): GHRP-6 produced a significant increase in GH and IGF-1 levels in healthy male subjects without impacting cortisol or prolactin. [JCEM. 1997;82(11):3572–3577.]
2. Appetite Stimulation (2000, Eur J Endocrinol): GHRP-6 increased appetite and caloric intake in underweight subjects through ghrelin-like signaling. [Eur J Endocrinol. 2000;142(5):522–528.]
3. Tissue Repair and Inflammation Reduction (2006, Peptides): Animal models treated with GHRP-6 showed accelerated wound healing and decreased inflammatory markers. [Peptides. 2006;27(8):1855–1863.]

Packaging Information:

• Form: Lyophilized powder
• Purity: ≥ 99%
• Storage: Store at -20°C in a dry, dark environment
• For research use only. Not for human or veterinary use.