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GHRP-2

GHRP-2

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$32.00
$32.00
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GHRP-2 (Pralmorelin) — Hexapeptide Ghrelin Receptor Agonist

GHRP-2 (USAN: Pralmorelin) is a synthetic growth-hormone secretagogue that activates the ghrelin receptor (GHSR-1a) on pituitary somatotrophs and hypothalamic neurons. It is used in research to study GH pulsatility, endocrine feedback, appetite signaling, and downstream IGF-1 biology.

Identifiers
  • Common names: GHRP-2; Pralmorelin; KP-102
  • CAS: 158861-67-7 (free base; salts may differ)
  • PubChem (example): CID 16129613
  • Sequence (hexapeptide): D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
  • Approx. MW: ~817 Da (form-dependent)
How It Works (Plain English)
  • GHRP-2 binds GHSR-1a → increases intracellular Ca2+ → stimulates GH release from the pituitary.
  • It works alongside GHRH (different receptor), so pairing with a GHRH analogue often amplifies GH pulses.
  • Compared with newer mimetics (e.g., Ipamorelin), GHRP-2 can show more prolactin/cortisol co-stimulation in some models—useful for endocrine mapping.
Why Researchers Use It
  • To model GH pulse dynamics and deconvolution analyses.
  • To study ghrelin-pathway pharmacology (appetite, hypothalamic circuits) separate from GHRH.
  • To compare ghrelin mimetics head-to-head (e.g., GHRP-2 vs Ipamorelin, GHRP-6).

Key Studies — What Was Tested, What Changed, Why It Matters

Human GH stimulation & diagnostic use
  • What was tested: GHRP-2 challenge in adults/children with serial GH sampling; clinical use as a GH-stimulation test in some regions.
  • What changed: Robust GH rises (peak and AUC), often greater than older secretagogues.
  • Why it matters: Provides a strong signal for endocrine physiology and assay calibration work.
Synergy with GHRH analogues
  • What was tested: Co-administration with GHRH or long-acting analogues.
  • What changed: Higher GH peaks and prolonged pulses vs either pathway alone.
  • Why it matters: Demonstrates dual-input control of the somatotroph—useful for protocol design and mechanism parsing.

Potential Research Applications

Endocrine Physiology

  • GH pulse profiling, deconvolution, and feedback studies
  • Somatostatin “tone” and counter-regulation experiments

Translational Models

  • IGF-1 kinetics, protein turnover, and body-composition endpoints
  • Appetite/ghrelin-axis readouts (hypothalamic pathways)

Comparative Pharmacology

  • GHRP-2 vs Ipamorelin vs GHRP-6 selectivity and endocrine “cleanliness”
  • GHSR-1a receptor pharmacodynamics and desensitization

Synergistic Peptides (for Study Design)

CJC-1295 (±DAC)

  • Why pair: Activates the GHRH receptor; dual-pathway stimulation boosts GH output.
  • Angle: Compare short-acting (no-DAC) vs extended (DAC) exposure with the same GHRP-2 pulse.

Ipamorelin

  • Why pair/compare: More selective GH secretagogue; use as a comparator for prolactin/cortisol spillover.
  • Angle: Endocrine panel (GH, IGF-1, PRL, cortisol) to map selectivity.

MOTS-c

  • Why pair: Energy-metabolism peptide to study GH/IGF-1 effects alongside mitochondrial endpoints.

Design Notes

  • Pre-specify sampling windows tightly—GH is time-sensitive and pulsatile.
  • Document fed/fasted state, sleep, and exercise—major GH modulators.

Known Concerns (Context)

  • Endocrine breadth: At effective GH doses, some models show PRL/cortisol co-stimulation—plan panels accordingly.
  • Desensitization risk: Frequent/high exposure may blunt responsiveness; schedule recovery periods in repeat-dose designs.
  • General: For laboratory research use only; not for human consumption or therapeutic use.

Specifications & Handling

  • Form: Lyophilized powder (lot-coded)
  • Purity: ≥ 98–99% (HPLC/MS verified)
  • Storage: ≤ −20 °C; protect from light/moisture
  • In solution: Prepare fresh aliquots; avoid repeat freeze–thaw; record vehicle and pH
  • Packaging: Tamper-evident; research-only labeling

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

GHRP-2 (Pralmorelin) Research Peptide | Ghrelin (GHSR-1a) Agonist | GH Pulsatility, Endocrine & Appetite Pathway Studies

Keywords: GHRP-2, Pralmorelin, KP-102, ghrelin receptor agonist, GHSR-1a, growth hormone secretagogue, GH pulse, endocrine research, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
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