BPC & TB Blend

BPC-157 & TB-500 Peptide Blend

Primary Function: Accelerated healing, inflammation reduction, tissue regeneration
Research Use: Injury recovery, muscle and tendon repair, joint health, systemic regeneration
Molecular Formula (combined):

• BPC-157: C62H98N16O22
• TB-500 (Thymosin Beta-4 Fragment): C212H350N56O78S

CAS Numbers:

• BPC-157: 137525-51-0
• TB-500: 77591-33-4

Description:
The BPC-157 & TB-500 blend combines two of the most well-studied regenerative peptides, each targeting different biological pathways involved in tissue repair, inflammation control, and cellular regeneration. Together, this synergistic pairing is studied extensively for soft tissue healing, joint protection, muscle recovery, and systemic anti-inflammatory effects. BPC-157 works primarily on the gut-brain axis and vascular integrity, while TB-500 promotes cell migration, angiogenesis, and actin upregulation, enabling rapid tissue repair.

Mechanism of Action:

• BPC-157:

  • Enhances angiogenesis and fibroblast migration
  • Promotes tendon, ligament, and gut lining repair
  • Modulates nitric oxide and VEGF pathways

• TB-500:

  • Increases cell mobility via actin regulation
  • Supports new blood vessel formation (angiogenesis)
  • Reduces inflammatory cytokines and fibrosis

Key Research Areas:

• Musculoskeletal and tendon healing
• Soft tissue injuries and joint repair
• Post-surgical recovery and inflammation control
• Intestinal integrity and systemic regeneration

History of Discovery:
BPC-157 was derived from a protein in human gastric juice by researchers in Croatia in the early 1990s, with early studies focusing on gut healing and angiogenesis.
TB-500 is a synthetic version of a fragment of Thymosin Beta-4, a peptide first discovered in the thymus in the 1960s. It was later isolated for its role in wound healing and cytoskeletal regulation.

Case Studies:

1. Tendon Healing Acceleration (2011, J Orthop Res): BPC-157 demonstrated significant improvements in Achilles tendon healing in rats, especially when combined with TB-500. [J Orthop Res. 2011;29(3):437–444.]
2. Cardiac Tissue Recovery (2004, FASEB J): TB-500 reduced scarring and improved cardiac function after induced myocardial infarction in animal models. [FASEB J. 2004;18(9):1031–1033.]
3. Gastrointestinal Protection (2009, Curr Pharm Des): BPC-157 preserved intestinal barrier integrity under NSAID-induced stress and promoted vascular repair. [Curr Pharm Des. 2009;15(7):778–789.]

Packaging Information:

• Form: Lyophilized powder (combined blend)
• Purity: ≥ 99%
• For research use only. Not for human or veterinary use.