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BAM-15

BAM-15

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$149.00
$149.00
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BAM15 — Mitochondrial Protonophore Uncoupler (Metabolic Tool Compound)

BAM15 is an orally bioavailable, mitochondria-targeted protonophore uncoupler that increases nutrient oxidation and energy expenditure in preclinical models without altering food intake or core temperature in those studies. 

Identifiers
  • Chemical name: N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
  • CAS No.: 210302-17-3
  • PubChem CID: 565708
  • Formula / MW: C16H10F2N6O • ~340.29 g·mol⁻¹


How It Works (Plain English)
  • Acts as a mitochondrial protonophore, dissipating the proton gradient across the inner mitochondrial membrane (mild uncoupling). 
  • Uncoupling increases substrate oxidation and heat release in mitochondria, shifting whole-body metabolism toward higher energy expenditure in vivo models. 
  • Unlike older uncouplers, BAM15 is reported not to depolarize the plasma membrane in vascular cells at effective concentrations (mito-selective profile in those studies). 
Why Researchers Use It
  • To probe mechanisms of diet-induced obesity, insulin resistance, and hepatic steatosis via increased energy expenditure. 
  • To study insulin sensitivity using clamp techniques and lipidomics/metabolomics endpoints. 
  • To evaluate uncoupling in inflammation, sepsis, and oncology models. 

Key Studies — What Was Tested, What Changed, Why It Matters

Diet-Induced Obesity & Insulin Resistance (mouse)
  • What was tested: Oral BAM15 in high-fat-diet mice; body composition, food intake, indirect calorimetry, lipidomics, and euglycemic clamps.
  • What changed: ↓ fat mass, ↑ nutrient oxidation, improved insulin sensitivity without changes in food intake or body temperature; no clinical chemistry toxicity signals reported in study.
  • Why it matters: Positions mitochondrial uncoupling as a lever for energy expenditure with favorable metabolic effects. 
Protection Against Obesity & Glycemic Control
  • What was tested: BAM15-mediated uncoupling in DIO mice; glucose/lipid metabolism and adiposity outcomes.
  • What changed: ↓ adiposity, improved glucose tolerance/insulin sensitivity, better lipid handling.
  • Why it matters: Supports use in metabolic-syndrome research pipelines. 
Broader Applications (reviews & translational angles)
  • What’s reported: Review articles summarize possible roles in lowering hepatic glucose output, anti-inflammation, and organ aging biology through mito-metabolic reprogramming.
  • Implication: Useful as a tool compound to dissect uncoupling across tissues and diseases (endocrine, immune, oncology). 

Potential Research Applications

Metabolic Disease Models

  • Diet-induced obesity, hepatic steatosis, insulin resistance

Mitochondrial Bioenergetics

  • Respirometry (OCR), coupling/uncoupling parameters, ROS and membrane-potential assays

Inflammation & Oncology

  • Sepsis and macrophage activation models; tumor metabolism and proliferative fitness

Synergistic / Comparator Agents

MOTS-c or SS-31

  • Why pair: Contrast mitochondrial-uncoupling (BAM15) with mitochondrial-support peptides for combined bioenergetics panels.

GLP-1 / Cagrilintide (comparator)

  • Why compare: Appetite-centric vs energy-expenditure-centric weight-loss mechanisms.

AMPK Activators (e.g., AICAR)

  • Why compare: AMPK-first vs uncoupling-first metabolic remodeling.

Known Concerns (Context)

  • Tool-compound status: Evidence is preclinical; human PK/safety not established. 
  • Thermogenesis/ROS: Uncoupling alters proton motive force and can affect ROS; dose-response and tissue specificity are critical. 
  • Selectivity vs plasma membrane: Reports of minimal plasma-membrane depolarization at effective doses, but verify in your system. 
  • General: For laboratory research use only; not for human consumption or therapeutic use.

Specifications & Handling

  • Form: Small-molecule solid (lot-coded)
  • Purity: Research-grade (HPLC/MS)
  • Storage: Cool, dry; protect from light/moisture


  • In solution: Soluble in DMSO; record solvent %, pH, and time-to-assay; minimize freeze–thaw
  • Labeling: Tamper-evident; research-use-only; CAS and lot displayed

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

BAM15 Research Compound | Mitochondrial Uncoupler | Energy Expenditure, Obesity & Bioenergetics Studies

Keywords: BAM15, mitochondrial uncoupler, protonophore, energy expenditure, insulin sensitivity, hepatic steatosis, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
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