BAM-15

BAM-15

Primary Function: Mitochondrial uncoupler, fat oxidation, metabolic enhancement
Research Use: Obesity, fatty liver disease, mitochondrial research, longevity studies
Molecular Formula: C17H14ClFN3OS
CAS Number: 2030077-06-1
Synonyms: BAM15, Mitochondrial protonophore BAM-15

Description:
BAM-15 is a novel mitochondrial uncoupler known for its ability to increase energy expenditure without raising core body temperature—a major limitation of previous uncouplers like DNP. BAM-15 works by dissipating the proton gradient across the mitochondrial membrane, thereby enhancing fat oxidation, reducing reactive oxygen species (ROS), and improving insulin sensitivity in preclinical models. It is currently under investigation for applications in obesity, non-alcoholic fatty liver disease (NAFLD), and lifespan extension.

Mechanism of Action:

• Uncouples oxidative phosphorylation in mitochondria
• Increases fatty acid oxidation and metabolic rate
• Decreases mitochondrial ROS production
• Improves insulin sensitivity and reduces adiposity in animal models

Key Research Areas:

• Obesity and weight loss
• Mitochondrial health and bioenergetics
• Type 2 diabetes and insulin resistance
• Longevity and oxidative stress reduction

History of Discovery:
BAM-15 was developed by researchers in 2014 during a screening of small molecules aimed at safe mitochondrial uncoupling. Unlike earlier uncouplers (e.g., DNP), BAM-15 does not increase body temperature or exhibit significant toxicity at therapeutic doses in mice. This has made it a promising compound for metabolic disease and aging-related dysfunction.

Case Studies:

1. Fat Mass Reduction in Obese Mice (2017, Nature Communications): BAM-15 significantly reduced body weight, fat mass, and fasting glucose without affecting lean mass or temperature. [Nat Commun. 2017;8:14767.]
2. NAFLD Reversal and Liver Protection (2020, Cell Metab): BAM-15 improved liver histology, reduced steatosis, and improved metabolic markers in fatty liver models. [Cell Metab. 2020;32(3):401–413.]
3. Improved Mitochondrial Health and Reduced ROS (2019, Aging Cell): Mitochondrial efficiency and oxidative damage were significantly improved in aging models treated with BAM-15. [Aging Cell. 2019;18(6):e13016.]

Packaging Information:

• Form: Research-grade capsules
• Purity: ≥ 99%
• Storage: Store in dry, dark environment
• For research use only. Not for human or veterinary use.