9-ME-BC

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$112.00

Sale Sold out

Shipping calculated at checkout.

Capsule Quantity 60 120

9-ME-BC — 9-Methyl-β-carboline (Dopaminergic Research Compound)

9-ME-BC is a substituted β-carboline explored in neuroscience for its effects on dopaminergic neuron biology, microglial signaling, and monoamine oxidase (MAO) activity. In preclinical settings it’s used to study neurite outgrowth, neuroinflammation, and energy metabolism pathways relevant to dopaminergic systems.

Identifiers

CAS: 2521-07-5
PubChem CID: 164979
Formula / MW: C₁₂H₁₀N₂ · 182.22 g/mol
Preferred name: 9-Methyl-9H-pyrido[3,4-b]indole (9-ME-BC)

How It Works (Plain English)

Preclinical studies suggest 9-ME-BC can up-regulate neurotrophic genes in dopaminergic models and modulate microglial activity
It has been shown to inhibit MAO activity in vitro, a pathway that affects dopamine metabolism (context varies by model).
Animal work indicates support of neurite outgrowth / dopaminergic differentiation and mitochondrial-related readouts.

Why Researchers Use It

To probe dopaminergic neuron maintenance and regeneration markers in vitro and in vivo.
To examine neuroinflammatory modulation via microglia-related assays.
To study monoamine metabolism through MAO-linked pathways and gene expression.

Key Studies — What Was Tested, What Changed, Why It Matters

Dopaminergic support & neurite outgrowth

What was tested: Primary midbrain cultures and rodent models assessing dopaminergic differentiation, neurite growth, and behavioral readouts.
What changed: Increased appearance of functional dopaminergic neurons in culture and restorative signals in vivo (mitochondrial and neurotrophin-related).
Why it matters: Provides a tool to study how small heterocycles influence dopamine-system plasticity and energy handling.

Neuroinflammation & microglia

What was tested: Glial activation markers and cytokine profiles after toxin or stress exposure.
What changed: Reduced microglial proliferation and anti-inflammatory shifts (chemotactic cytokines down).
Why it matters: Helps parse glia–neuron cross-talk when modeling dopaminergic injury or stress.

MAO activity & neurotrophic gene expression

What was tested: In-vitro MAO assays and gene-expression panels in dopaminergic cell models.
What changed: 9-ME-BC inhibited MAO activity and up-regulated genes like BDNF, ARTN, and others tied to neuron support.
Why it matters: Links monoamine metabolism with pro-trophic signaling in a single small molecule model.

Potential Research Applications

Dopaminergic Systems

Neurite outgrowth and synaptic markers
Mitochondrial/respiratory chain assays

Neuroinflammation

Microglial proliferation & cytokine profiling
Neuron–glia co-culture models

Monoamine Metabolism

MAO activity panels (A/B)
Dopamine turnover and gene-expression arrays

Synergistic Research Pairings

Semax / Selank

Why pair: Neuroplasticity and neuroimmune modulators that complement dopaminergic assays.
Angle: Combine behavioral tasks with BDNF/cytokine panels to probe converging mechanisms.

SS-31 (Elamipretide) (if offered)

Why pair: Mitochondria-targeted peptide for bioenergetic endpoints alongside 9-ME-BC.
Angle: High-resolution respirometry + neurite/microglia markers.

GHK-Cu / BPC-157

Why pair: Tissue microenvironment and repair-signaling complements for multi-pathway designs.
Angle: ECM + neuronal markers in mixed cultures or injury paradigms.

Design Notes

Document solvent/vehicle (β-carbolines are light-sensitive heteroaromatics).
Include MAO controls and parallel trophic-gene assays for mechanism clarity.
Pre-define glial vs neuronal endpoints to separate effects by cell type.

Known Concerns (Context)

Concentration-dependent effects: β-Carbolines can show cytotoxicity at higher micromolar ranges in some cell lines; titrate and include viability controls.
MAO interaction: Inhibition of MAO activity means monoamine levels can shift—design.
Handling hazards: Causes skin/eye irritation per SDS; use PPE and handle in a fume hood.

Specifications & Handling

Form: Crystalline powder (lot-coded)
Purity: ≥ 98–99% (HPLC; supplier/lot dependent)
Storage: Protect from light; keep tightly closed; cool, dry conditions

In solution: Prepare fresh, light-protected aliquots; verify stability in chosen solvent
Additives: None unless specified per lot
Packaging: Tamper-evident; research-only labeling

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

9-ME-BC (9-Methyl-β-carboline) Research | Dopaminergic Neuron, MAO Activity & Microglia Modulation

Keywords: 9-ME-BC, 9-Methyl-β-carboline, dopaminergic neurons, MAO inhibitor, microglia, neurite outgrowth, mitochondrial function, Base Peptides.

View full details

Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.

Keep Shopping