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Thymosin Alpha 1

Thymosin Alpha 1

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$49.00
$49.00
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Thymosin-α1 (Tα1 / Thymalfasin) — 28-Amino-Acid Immune-Signaling Peptide

Thymosin-α1 is a naturally occurring 28-residue peptide generated from prothymosin-α. In research, it’s used to study innate–adaptive immune coordination, dendritic-cell/T-cell activation, and antiviral host-defense signaling. 

Identifiers
  • CAS: 62304-98-7 
  • PubChem CID (Thymalfasin): 16130571 
  • Formula / MW: C129H215N33O55 · ≈ 3,108 Da 
  • Sequence (human): Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH (28 aa) 
  • Origin: N-terminally acetylated fragment of prothymosin-α (PTMA) 
How It Works (Plain English)
  • Tα1 engages innate sensors (reported activity at TLR2/TLR9 on antigen-presenting cells) that help prime adaptive T-cell responses. 
  • It’s often used to explore Th1-leaning immune balance, antigen presentation, and antiviral gene programs in preclinical systems. 
  • Because it’s a defined peptide, researchers can test dose–response and timing with clean readouts vs. complex biologics.
Why Researchers Use It
  • To study dendritic-cell maturation and T-cell priming in vitro/in vivo models. 
  • To analyze host-defense pathways in viral or bacterial challenge paradigms. 
  • To map innate–adaptive cross-talk with precise peptide exposures. 

Key Studies — What Was Tested, What Changed, Why It Matters

Innate sensors → adaptive activation
  • What was tested: Antigen-presenting cell exposure to Tα1 with downstream T-cell readouts.
  • What changed: Increased markers of APC activation and improved T-cell responses in multiple models. 
  • Why it matters: Helps labs dissect how short peptides can bridge innate and adaptive immunity.
Antiviral & host-defense signaling
  • What was tested: Preclinical and clinical-context literature on Tα1 in viral disease models (e.g., hepatitis; respiratory infections).
  • What changed: Reports of enhanced cell-mediated immunity and improved immune balance; findings vary by model and cohort. 
  • Why it matters: Offers a mechanistic tool for probing antiviral readiness and Th1/Th2 balance in controlled settings.
Translational context (regulatory/overview)
  • What was reviewed: FDA background summary on Tα1 bulk substance chemistry (free base vs salt), formula, and safety testing ranges.
  • Key notes: Confirms CAS 62304-98-7, formula C129H215N33O55, and provides nonclinical exposure ranges; use for research-context only here. 

Potential Research Applications

Innate → Adaptive Mapping

  • APC maturation and antigen-presentation assays
  • Th1/Th2 cytokine panels and T-cell function

Host-Defense Models

  • Antiviral readiness and interferon-linked genes
  • Vaccinology adjuvant-style investigations

Systems Immunology

  • Gene-expression arrays and pathway enrichment
  • Time-course designs for dose/timing effects

Synergistic Peptides (for Study Design)

Selank

  • Why pair: Neuroimmune balancing—useful alongside Tα1’s immune-priming studies.
  • Angle: Cytokine profiles (Th1/Th2) plus behavioral-stress markers.

BPC-157

  • Why pair: Tissue/gut barrier models with inflammatory readouts that complement immune signaling.
  • Angle: Barrier function + cytokine panels in co-culture systems.

TB-500 (Tβ4 fragment)

  • Why pair: Matrix/motility signaling to contrast with immune-centric endpoints.
  • Angle: ECM markers + immune-cell recruitment in repair-biology models.

Design Notes

  • Define timing (pre-, co-, or post-challenge) and dose precisely—immune outputs are time-dependent.
  • Use standardized media/serum lots; cytokine assays are sensitive to background noise.
  • Document peptide salt/form, vehicle, pH, light exposure, and storage.

Known Concerns (Context)

  • Model variability: Outcomes depend on pathogen type, challenge dose, and host model/strain.
  • Assay design: Include both innate and adaptive endpoints to avoid partial interpretations.
  • General: Research use only; not for human consumption or therapeutic use.

Handle under cold, low-light conditions; prepare fresh aliquots and avoid repeat freeze–thaw cycles.

Specifications & Handling

  • Form: Lyophilized powder (lot-coded)
  • Purity: ≥ 99% (HPLC/MS verified)
  • Storage: ≤ −20 °C; protect from light/moisture
  • In solution: Aliquot promptly; avoid repeat freeze–thaw
  • Additives: None unless specified per lot
  • Packaging: Tamper-evident; research-only labeling

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

Thymosin-alpha 1 (Tα1, Thymalfasin) Peptide Research | Immune Signaling, APC/T-cell Activation, Antiviral Host Defense

Keywords: Thymosin alpha 1, Thymalfasin, Tα1 peptide, prothymosin-α fragment, TLR2 TLR9 signaling, dendritic cell, T-cell priming, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
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