Tesofensine Tablets 500mcg

5-Amino-1MQ Capsules

Primary Function: Fat metabolism, NAD+ preservation, weight management support
Research Use: Obesity research, fat cell regulation, NNMT inhibition, NAD⁺ conservation
Molecular Formula: C6H9N5
CAS Number: 14027-96-0
Synonyms: 5-Amino-1-methylquinolinium, NNMT inhibitor, 5-Amino-1MQ

Description:
5-Amino-1MQ is a small molecule compound that functions as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme heavily expressed in fat tissue and linked to metabolic slowdown. By inhibiting NNMT, 5-Amino-1MQ helps preserve intracellular NAD⁺ levels, enhance energy metabolism, and stimulate lipolysis. Research has shown its potential for fat loss, mitochondrial support, and improving insulin sensitivity.

Now available in capsule form, this compound offers oral delivery convenience for research focused on systemic metabolic pathways.

Mechanism of Action:

• Inhibits NNMT, reducing NAD⁺ methylation and degradation
• Increases cellular NAD⁺ availability, supporting sirtuin and mitochondrial function
• Enhances lipolysis and reduces adipocyte size in white fat tissue
• Promotes metabolic rate elevation and fat oxidation

Key Research Areas:

• Obesity and metabolic syndrome
• NAD⁺ preservation and mitochondrial health
• Type 2 diabetes and insulin resistance
• Fatty liver and lipid regulation

History of Discovery:
5-Amino-1MQ was developed following studies identifying NNMT as a key regulator of metabolic efficiency and adipogenesis. Scientists discovered that inhibition of NNMT in fat cells led to smaller adipocytes, improved insulin signaling, and increased NAD⁺-dependent gene expression, opening the door to therapeutic strategies targeting fat metabolism and cellular energy regulation.

Case Studies:

1. Fat Reduction in Obese Mice (2017, Biochem Pharmacol): 5-Amino-1MQ treatment reduced body weight and improved insulin sensitivity by inhibiting NNMT and boosting NAD⁺. [Biochem Pharmacol. 2017;132:80–90.]
2. Adipocyte Size & Energy Expenditure (2020, Cell Metab): NNMT inhibition via 5-Amino-1MQ led to smaller fat cells and higher oxygen consumption. [Cell Metab. 2020;31(1):84–96.]
3. Improved Lipid Profile (2021, Metabolism Open): Supplementation improved triglyceride levels and reduced hepatic fat content in diet-induced obese models. [Metabolism Open. 2021;10:100108.]

Packaging Information:

• Form: Oral capsule 
• Purity: ≥ 99%
• Storage: Store in a cool, dry place away from light
• For research use only. Not for human or veterinary use.