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Selank

Selank

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$35.00
$35.00
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Selank — Synthetic Heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro)

Selank is a short synthetic peptide derived from the Tuftsin sequence, designed to mimic its natural immune-modulating and neuropeptide effects. It’s used in research to study stress adaptation, cognitive support, GABAergic signaling, and immune balance.

Identifiers
  • CAS: 129954-34-3
  • PubChem CID: 10409719
  • Formula / MW: C33H57N11O9 · ≈ 751.9 Da
  • Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
  • Origin: Analogue of the endogenous peptide Tuftsin (Thr-Lys-Pro-Arg)
How It Works (Plain English)
  • Selank interacts with GABA and serotonin systems, which are important in mood, stress, and focus regulation.
  • It also appears to modulate cytokine balance, linking the nervous and immune systems through shared signaling molecules.
  • Researchers use it to study how short neuroactive peptides may stabilize stress responses and support cognitive resilience.
Why Researchers Use It
  • To explore neuroimmune signaling in stress or anxiety models.
  • To analyze GABA-A receptor modulation and neurotransmitter gene expression.
  • To study peptide-based anxiolytic mechanisms without sedation or dependency pathways.

Key Studies — What Was Tested, What Changed, Why It Matters

Stress and anxiety-response models
  • What was tested: Selank in animal models exposed to chronic stress or anxiety stimuli.
  • What changed: Reduced anxiety-like behavior and normalized GABA/glutamate ratios were observed.
  • Why it matters: Suggests Selank influences stress resilience through fine-tuning of inhibitory signaling rather than direct sedation.
Cognitive and memory function studies
  • What was tested: Performance on learning and memory tasks after Selank exposure.
  • What changed: Improved retention and task performance, potentially linked to serotonin and BDNF gene regulation.
  • Why it matters: Highlights how small peptides can modulate neuroplasticity and neurotransmitter signaling.
Immune modulation and cytokine balance
  • What was tested: Cytokine profiles after Selank administration in immunologic challenge models.
  • What changed: More balanced Th1/Th2 responses and reduced pro-inflammatory cytokines.
  • Why it matters: Demonstrates Selank’s unique positioning as a neuroimmune modulator bridging mental and immune stress pathways.

Potential Research Applications

Neuroscience Models

  • GABAergic modulation and neurotransmitter balance
  • Memory, focus, and behavioral-stress paradigms

Immune & Inflammatory Pathways

  • Th1/Th2 cytokine profiling and immune-stress cross-talk
  • Neuroimmune peptide mechanisms

Peptide Analog Research

  • Comparison to Tuftsin, Semax, and related neuropeptides
  • Synergy with neurotrophic or stress-response pathways

Synergistic Peptides (for Study Design)

Semax

  • Why pair: Another ACTH-derived neuropeptide with complementary cognitive and anti-stress activity.
  • Angle: Combined models to explore cognition, focus, and neuroprotection.

BPC-157

  • Why pair: Adds systemic and gut-brain repair elements to Selank’s CNS-focused profile.
  • Angle: Cross-organ stress resilience and cytokine modulation studies.

GHK-Cu

  • Why pair: Enhances tissue and neurotrophic gene expression; ideal for repair-focused designs.
  • Angle: Evaluate BDNF, collagen, and inflammatory markers in joint models.

Design Notes

  • Standardize exposure duration (Selank is short-acting in solution).
  • Include behavioral and molecular endpoints together for context.
  • Protect from oxidation and light; short peptides degrade easily in aqueous media.

Known Concerns (Context)

  • Stability: Short peptides like Selank are solution-sensitive; always prepare fresh aliquots.
  • Model dependence: Behavioral data can vary by environment; ensure consistent stress protocols.
  • General: For laboratory research use only; not for therapeutic or human consumption.

Handle under cold, low-light conditions; verify purity before use in molecular assays.

Specifications & Handling

  • Form: Lyophilized powder (lot-coded)
  • Purity: ≥ 99% (HPLC/MS verified)
  • Storage: ≤ −20 °C; protect from light/moisture
  • In solution: Aliquot promptly; avoid repeat freeze–thaw
  • Additives: None unless specified per lot
  • Packaging: Tamper-evident; research-only labeling

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

Selank Peptide Research | Synthetic Heptapeptide | GABAergic, Neuroimmune & Stress-Response Studies

Keywords: Selank peptide, Tuftsin analogue, heptapeptide, GABA modulation, neuroimmune research, anxiety model, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
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