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RAD

RAD

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$140.00
$140.00
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RAD140 (Testolone) — Selective Androgen Receptor Modulator (SARM)

RAD140—also known as Vosilasarm / EP0062—is an orally active, non-steroidal selective androgen receptor modulator (SARM) used in research on muscle & bone biology, neuroprotection, and androgen-receptor–positive oncology.

Identifiers
  • Synonyms: RAD140; Testolone; Vosilasarm; EP0062
  • CAS No.: 1182367-47-0
  • Molecular Formula: C20H16ClN5O2 • MW: ~393.8 g·mol⁻¹
  • Class: Non-steroidal AR agonist / SARM (oral)
  • Reported t1/2 (models): ~45–60 h (literature reports; study-dependent)
How It Works (Plain English)
  • Binds the androgen receptor (AR) with tissue selectivity, promoting anabolic signaling in muscle and bone while aiming to limit classic androgenic effects in other tissues.
  • In neural models, AR activation by RAD140 showed neuroprotective effects against apoptotic stressors.
  • In AR-positive breast-cancer models, RAD140 acted as a selective AR agonist with AR-mediated repression of ER pathways (distinct from testosterone/androgens).
Why Researchers Use It
  • Probe skeletal muscle hypertrophy, protein turnover, and bone markers in preclinical systems.
  • Interrogate neuron survival/stress-resistance pathways via AR signaling.
  • Evaluate AR-positive, ER-negative oncology mechanisms and AR-ER crosstalk.

Key Study Themes — What Was Tested, What Changed, Why It Matters

Neuroprotection (in vitro & rodent)
  • What was tested: Cultured hippocampal neurons and kainate-lesioned rats exposed to RAD140 vs testosterone.
  • What changed: RAD140 was as effective as testosterone in reducing apoptotic cell death; supported neuronal survival in vivo.
  • Why it matters: Highlights AR-driven protective signaling in neural tissue beyond classic anabolic targets.
AR-Positive Breast Cancer (translational)
  • What was tested: AR-positive breast-cancer cell and xenograft models; early-phase human trials have explored safety/pharmacology.
  • What changed: RAD140 showed potent AR agonism and AR-mediated repression of ESR1/ER signaling in preclinical work; Phase 1 first-in-human study reported feasibility and characterized exposure/safety.
  • Why it matters: Provides a research path for AR-targeted strategies distinct from steroidal androgens.
Muscle & Functional Outcomes (preclinical)
  • What was tested: Rodent models assessing hypertrophy/overload, frailty indices, grip strength, and recovery with SARM exposure.
  • What changed: Studies report anabolic/functional effects that are design-dependent (some mixed findings in aging models).
  • Why it matters: Useful comparator for SARMs vs GH/IGF-axis interventions.

Potential Research Applications

Muscle & Bone Biology

  • Myotube protein synthesis, muscle CSA, bone-turnover markers

Neurobiology

  • Apoptosis resistance, neurite integrity, stress-response panels

Oncology (AR-Positive)

  • AR agonism, AR–ER crosstalk, growth/response signatures

Synergistic / Comparator Agents

MK-677 (GHSR-1a agonist)

  • Why compare: GH/IGF-1–axis vs direct AR agonism for anabolic endpoints.

Tesamorelin / CJC-1295+Ipamorelin

  • Why pair/compare: Pituitary-driven endocrine strategies vs SARM receptor-level signaling.

Ostarine / LGD-4033 (comparators)

  • Why compare: Benchmark anabolic selectivity and safety panels across SARM classes.

Known Concerns (Context)

  • Regulatory status: Investigational; not an approved therapeutic indication in many jurisdictions.
  • Liver & cardio panels: Case reports link black-market SARM products to drug-induced liver injury; ensure rigorous QC and model-appropriate monitoring.
  • Endocrine feedback: AR-pathway agents may influence endogenous hormone axes; include comprehensive panels where relevant.
  • General: For laboratory research use only; not for human consumption or veterinary/medical use.

Specifications & Handling

  • Form: Small-molecule solid (lot-coded)
  • Purity: Research-grade (HPLC/MS)
  • Storage: Cool, dry; protect from light/moisture
  • In solution: Soluble in DMSO/ethanol—document solvent %, pH, and time-to-assay; minimize freeze–thaw
  • Labeling: Tamper-evident; CAS/lot/SKU clearly displayed; “research use only”

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

RAD140 (Testolone) Research Compound | Selective Androgen Receptor Modulator | Muscle, Neuroprotection & AR-Positive Oncology Studies

Keywords: RAD140, Testolone, Vosilasarm, EP0062, selective androgen receptor modulator, SARM, AR agonist, neuroprotective SARM, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
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