PT-141

PT-141, also known as Bremelanotide, is a synthetic peptide that targets melanocortin receptors involved in sexual arousal and libido.

Originally developed as a tanning agent, PT-141 was developed by Palatin Technologies and initially investigated as a potential treatment for erectile dysfunction (ED) and female sexual dysfunction (FSD).

It works as a melanocortin receptor agonist, specifically targeting the melanocortin receptors MC3-R and MC4-R in the central nervous system. By activating these receptors, PT-141 enhances sexual arousal and desire.

Potential Benefits & Mechanism of Action:

• Treatment for Erectile Dysfunction: PT-141 offers an alternative to traditional ED treatments like Viagra by directly targeting the central nervous system and enhancing sexual arousal

• Treatment for Female Sexual Dysfunction: PT-141 has shown promise in treating FSD by increasing libido and sexual satisfaction in women

• Non-Hormonal: Unlike some other sexual dysfunction treatments, PT-141 works independently of hormonal pathways, making it suitable for individuals with hormone-related conditions or those who cannot tolerate hormonal therapies.

Case Studies:

• Animal Studies: Preclinical studies in animals, particularly rodents, have demonstrated PT-141's ability to increase sexual behavior and arousal, supporting its potential efficacy in humans

• Human Trials: Clinical trials have shown positive results in both men and women with sexual dysfunction. In one study, men with ED experienced improvements in erectile function after PT-141 administration, while in another study, women with FSD reported increased sexual desire and satisfaction.

PT-141 activates melanocortin receptors in the brain, enhancing sexual arousal independently of hormone levels.

Clinical trials have shown PT-141 is effective in increasing sexual desire and function in both men and women. It is now commercially available under the brand name Vyleesi.