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P21

P21

Regular price $90.00
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P21, also known as Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A), is a regulatory protein crucial for cell cycle control. It has gained significant attention in research due to its roles in cellular senescence, DNA repair, and tumor suppression. Below is a comprehensive review of its history, clinical trials, and potential benefits.

History

  • Discovery: p21 was first identified in the early 1990s as a key mediator of p53 tumor suppressor activity, playing a critical role in cell cycle arrest.
  • Biological Role: Acts as an inhibitor of cyclin-dependent kinases (CDKs), regulating the G1/S and G2/M transitions in the cell cycle.
  • Connection to Aging and Cancer: Its role in inducing cellular senescence links it to aging processes and its potential as a tumor suppressor.

Clinical Trials

  • Preclinical Studies: Investigated in vitro and in vivo models for its ability to induce cell cycle arrest and promote DNA repair mechanisms.
  • Cancer Research: Ongoing studies are exploring p21 as a therapeutic target in various cancers, particularly in p53-mutated tumors where its independent pathways may be exploited.
  • Tissue Regeneration: Early trials suggest that manipulating p21 levels could enhance tissue regeneration by controlling cellular proliferation and differentiation.
  • Drug Development: Compounds targeting the modulation of p21 activity are in development, aiming to harness its protective effects while avoiding the risks of unchecked cell cycle inhibition.

Benefits

  • Tumor Suppression: p21’s ability to induce cell cycle arrest helps prevent the proliferation of damaged or cancerous cells.
  • DNA Repair: Plays a critical role in stabilizing the genome by allowing time for DNA repair processes during cell cycle arrest.
  • Cellular Senescence: Promotes a controlled entry into senescence, which can prevent malignant transformation and contribute to aging regulation.
  • Anti-Inflammatory Potential: Studies indicate p21 involvement in suppressing pro-inflammatory cytokine production, particularly in chronic conditions.
  • Tissue Regeneration: By balancing cell cycle regulation, p21 may enhance regenerative medicine strategies, especially in degenerative diseases.
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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.