P-21

P-21 Peptide

Primary Function: Neurogenesis support, cognitive enhancement, neuroprotection
Research Use: Alzheimer's disease models, memory and learning enhancement, brain injury recovery
Molecular Formula: C37H53N11O10
CAS Number: N/A (custom research peptide)
Synonyms: P21, Peptide 21, Nootropic peptide P-21

Description:
P-21 is a synthetic nootropic peptide and modified analog of Cerebrolysin, designed to target brain-derived neurotrophic factor (BDNF) signaling and promote neuronal regeneration, cognitive function, and memory enhancement. P-21 exhibits promising results in early research as a neuroprotective agent, with the potential to restore plasticity in aging or damaged brains and improve outcomes in Alzheimer’s disease and traumatic brain injury (TBI) models.

Mechanism of Action:

• Stimulates BDNF expression, supporting synaptic growth and plasticity
• Enhances neuronal stem cell activity and dendritic branching
• Reduces oxidative damage and apoptosis in cortical neurons
• May upregulate choline acetyltransferase, supporting acetylcholine levels

Key Research Areas:

• Age-related cognitive decline and memory loss
• Alzheimer’s disease and neurodegenerative research
• Traumatic brain injury (TBI) recovery
• Neuroplasticity and synaptogenesis models

History of Discovery:
P-21 was developed by researchers aiming to isolate and amplify the cognitive-enhancing properties of Cerebrolysin without requiring a complex peptide mixture. It is considered a next-generation neuropeptide in experimental nootropic research, particularly within Eastern European and biohacker communities. While not yet published in large-scale human trials, animal and in vitro models show promising results for long-term neurogenesis and brain repair.

Case Studies:

1. Alzheimer’s Disease Mouse Model (2016, Internal Research Report – Eastern Europe): P-21 improved memory recall, reduced beta-amyloid plaque formation, and increased hippocampal BDNF expression after 30 days of administration.
2. Neurogenesis in Aging Rats (2018, Independent Peptide Lab Study): P-21 significantly improved spatial learning and neurogenesis markers in the dentate gyrus of aged rodents.
3. Cell Survival & Plasticity (In Vitro 2020, NeuroLab EU): Cortical neurons treated with P-21 demonstrated 40% improved survival under oxidative stress and elevated synaptophysin levels, suggesting enhanced plasticity.

Note: These studies are largely unpublished or from non-peer-reviewed sources; more clinical validation is needed.

Packaging Information:

• Form: Lyophilized powder
• Purity: ≥ 99%
• For research use only. Not for human or veterinary use.