P-21
P-21
Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.
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P-21 Peptide
A synthetic neurotrophic-style peptide derived from the active region of Ciliary Neurotrophic Factor (CNTF), designed for research into neurogenesis, cognitive support, and neuronal repair.
Key Identifiers & Facts
| INCI/Name | P-21 (also known as P021) |
|---|---|
| Sequence / Structure | Derived from amino acids 148-151 of CNTF; modified for CNS penetration. [oai_citation:0‡The International Peptide Society](https://peptidesociety.org/_template-monographs-5/?utm_source=chatgpt.com) |
| Research Focus | Neuro-protection, neuro-genesis, cognitive resilience. [oai_citation:1‡Georgia Today](https://georgiatoday.ge/an-in-depth-exploration-of-the-p21-peptide/?utm_source=chatgpt.com) |
How It Works (Readable Format)
- It mimics a small fragment of CNTF to trigger signalling pathways tied to neuronal survival and growth.
- By potentially enhancing neuronal plasticity and growth factor expression, it may support brain resilience under stress. [oai_citation:2‡Core Peptides](https://www.corepeptides.com/p21-peptide-research-in-neurological-disorders-and-appetite/?utm_source=chatgpt.com)
- Early studies indicate benefits in neural tissue models for repair and structural support. [oai_citation:3‡Peptide Sciences](https://www.peptidesciences.com/peptide-research/p21-neurodegeneration-alzheimers-tau-beta-amyloid-plaques?utm_source=chatgpt.com)
Potential Applications & Research Highlights
- Supports neurogenesis—early animal/ in-vitro models show increased marker expression for new neuron formation. [oai_citation:4‡Georgia Today](https://georgiatoday.ge/an-in-depth-exploration-of-the-p21-peptide/?utm_source=chatgpt.com)
- May support cognitive function and resilience in models of neuronal injury or degeneration. [oai_citation:5‡Core Peptides](https://www.corepeptides.com/p21-peptide-research-in-neurological-disorders-and-appetite/?utm_source=chatgpt.com)
- Because it is a small fragment engineered for CNS uptake, it opens pathways for brain-focused peptide research beyond larger neurotrophins. [oai_citation:6‡Peptide Sciences](https://www.peptidesciences.com/p21-p021-5mg?utm_source=chatgpt.com)
Known Considerations
- Primarily preclinical data—human clinical trials are limited or not publicly published.
- As with any neuro-active peptide, effects may vary and caution is advised in research protocols.
Synergistic Peptides
- Pair with cognitive/neuro-repair peptides such as Semax or Selank for broader neural support.
- Combine with antioxidant/mitochondrial support peptides (e.g., Methylene Blue formulations) for enhanced neuronal environment optimisation.
*For research-use only. Not approved for therapeutic use. Always consult primary literature and ensure ethical protocols when working with neuro-active peptides.
