NAD+

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

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NAD⁺ — Nicotinamide Adenine Dinucleotide (Oxidized) • Injectable Research Grade

NAD⁺ is a ubiquitous pyridine nucleotide coenzyme central to cellular redox reactions and a substrate for sirtuins, PARPs, and other NAD-consuming enzymes. Injectable research formats are used to probe bioenergetics, mitochondrial function, DNA-repair signaling, and cell stress responses.

Identifiers

Synonyms: β-NAD; Coenzyme I; DPN⁺
CAS No.: 53-84-9
Chemical formula / MW: C₂₁H₂₇N₇O₁₄P₂ • ~663.43 g·mol⁻¹
Form: Oxidized nicotinamide adenine dinucleotide (NAD⁺)
Class: Redox cofactor; enzyme substrate

How It Works (Plain English)

Redox shuttle: Cycles between NAD⁺ and NADH to carry electrons in glycolysis, TCA cycle, and oxidative phosphorylation.
Signaling substrate: Consumed by sirtuins (protein deacetylation), PARPs (DNA-damage signaling), and CD38/CD157 (calcium/immune pathways), impacting transcription, repair, and stress resistance.
Compartment matters: Cytosolic vs mitochondrial NAD(H) pools can change outcomes; many studies track the NAD⁺/NADH ratio as a metabolic health marker.

Why Researchers Use It

To examine mitochondrial function, ATP production, and oxidative stress resilience.
To probe DNA repair and inflammatory signaling via PARP/CD38 activity.
To compare direct NAD⁺ provision vs precursors (NR, NMN, NaR) in pharmacology and kinetics models.

Key Study Themes — What’s Typically Observed

Bioenergetics & Mitochondrial Readouts

Endpoints: NAD⁺/NADH ratio, oxygen consumption rate (OCR), ATP levels, ROS, membrane potential.
Typical findings: Designs that raise cellular NAD⁺ often report improved redox balance and stress tolerance (model-dependent).
Notes: Effects vary by tissue, delivery route, and timing; confirm compartmental targeting.

DNA Damage / Repair & Inflammation

Endpoints: PARylation, γH2AX, sirtuin targets (e.g., PGC-1α deacetylation), cytokine panels.
Typical findings: Modulation of PARP/sirtuin pathways with downstream effects on repair and inflammatory tone in select models.
Design tip: Account for PARP activation draining NAD⁺ pools during acute DNA damage.

Potential Research Applications

Metabolism & Aging Biology

Redox balance, sirtuin activity, mitochondrial biogenesis markers.

Neuro & Cardio Stress Models

Ischemia/reperfusion, excitotoxicity, neuroinflammation panels.

Immunometabolism

CD38-linked NADase activity, macrophage polarization, cytokine output.

Synergistic / Comparator Compounds

NMN / NR (Precursors)

Why compare: Indirect vs direct NAD⁺ elevation; differing transport and conversion steps.

MOTS-c / SS-31

Why pair: Layer mitochondrial-support peptides with NAD⁺-dependent sirtuin biology.

Resveratrol / Urolithin A

Why compare: Sirtuin/mitophagy pathways that intersect with NAD⁺ availability.

What’s in the Vial (Editable)

Active	Per Vial	Grade / Purity
NAD⁺ (β-Nicotinamide Adenine Dinucleotide)	250 mg (set your SKU)	Research-grade, ≥ 98–99% (HPLC/MS)
Appearance	White to off-white solid; hygroscopic
Solubility	Water-soluble; prepare fresh sterile solution for lab use

Specifications & Handling

Form: Lyophilized powder for injectable research workflows (lot-coded)
Storage: ≤ −20 °C (dry, dark); minimize humidity and light exposure
Stability: Aqueous NAD⁺ is labile—use immediately after sterile preparation; avoid repeated freeze–thaw

Labeling: “Research Use Only”; CAS/lot/SKU, concentration after reconstitution, and expiration clearly displayed
QC (per lot): HPLC identity/purity, endotoxin/bioburden (if sterile-filtered vial), residual solvents, pH/osmolality (solution)

Known Concerns (Context)

Chemical sensitivity: Degrades with heat, light, and alkalinity; track pH and protect from UV.
Pathway crosstalk: High PARP activation can deplete NAD⁺; CD38 upregulation alters pools—design controls accordingly.
General: For laboratory research use only; not for human consumption or therapeutic/veterinary use.

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

NAD⁺ Injection Research | Nicotinamide Adenine Dinucleotide (Oxidized) | Mitochondrial Bioenergetics, Sirtuins & DNA-Repair Studies

Keywords: NAD+, nicotinamide adenine dinucleotide, β-NAD, coenzyme I, redox cofactor, sirtuins, PARP, mitochondrial function, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.

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