1 4

Kisspeptin

Kisspeptin

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$55.00
$65.00 $55.00
Sale Sold out
Shipping calculated at checkout.
Quantity

Kisspeptin — KISS1/Kp-10 Peptide (GPR54/KISS1R Agonist)

Kisspeptin peptides (from the KISS1 gene; historically “metastin”) activate the KISS1R/GPR54 receptor in the hypothalamus to drive GnRH release and downstream LH/FSH signaling. Researchers use kisspeptin to map the reproductive axis, pubertal timing, and hypothalamic pulse-generation.

Identifiers
  • Common research forms: Kisspeptin-10 (Kp-10), Kisspeptin-13, Kisspeptin-54
  • Receptor: KISS1R (GPR54), a GPCR on GnRH neurons
  • Sequence (Kp-10): Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (YNWNSFGLRF-NH2)
  • Class: Neuropeptide; hypothalamic–pituitary–gonadal (HPG) axis modulator
  • CAS: Variant-dependent (differs for Kp-10 / Kp-13 / Kp-54)
How It Works (Plain English)
  • Kisspeptin binds KISS1R on GnRH neurons → triggers GnRH secretion → pituitary release of LH/FSH.
  • Interacts with the hypothalamic KNDy neuron network (Kisspeptin/Neurokinin-B/Dynorphin) that helps pace the GnRH “pulse generator.”
  • Estradiol/testosterone feedback modulates kisspeptin tone, letting researchers probe sex-steroid feedback loops.
Why Researchers Use It
  • Reproductive axis mapping: Characterize GnRH/LH/FSH dynamics and pulse frequency.
  • Puberty & hypothalamic function: Explore timing of pubertal onset and hypothalamic responsiveness.
  • Comparative models: Evaluate differences in PCOS, hypothalamic amenorrhea, or hypogonadotropic contexts (preclinical/clinical research models).

Key Study Themes — What Was Tested, What Changed, Why It Matters

Acute LH/FSH Responses
  • What was tested: Single or short-pulse kisspeptin exposure; serial sampling of LH/FSH ± sex-steroid suppression.
  • What changed: Prompt, dose-dependent rises in LH (often >FSH) when the axis is receptive.
  • Why it matters: Confirms intact GnRH–pituitary signaling and informs pulse-timing paradigms.
Pulse Generator / KNDy Network
  • What was tested: Pulsatile vs continuous designs; co-manipulation with neurokinin-B or dynorphin analogs.
  • What changed: Pulsatile exposure supports physiologic-like LH pulses; continuous exposure may blunt responses (tachyphylaxis).
  • Why it matters: Helps distinguish pattern-dependent signaling across the HPG axis.
Translational Endpoints
  • What was tested: Axis responsiveness in varied cohorts (e.g., stress, energy deficiency models).
  • What changed: Context-dependent LH/FSH and steroid panels; informs hypothalamic sensitivity and feedback strength.
  • Why it matters: Useful for parsing hypothalamic drive vs pituitary/ovarian/testicular responsiveness in research settings.

Potential Research Applications

HPG Axis Physiology

  • GnRH/LH/FSH dynamics, steroid feedback, pulse-frequency mapping.

Puberty & Timing

  • Hypothalamic activation thresholds, sex-steroid priming, developmental studies.

Comparative Endocrinology

  • KNDy neuron interactions; neurokinin-B/dynorphin modulation.

Synergistic / Comparator Agents

Gonadorelin (GnRH)

  • Why compare: Downstream hypothalamic output vs upstream kisspeptin trigger.

Neurokinin-B (NKB) / Dynorphin A

  • Why pair: Dissect the KNDy triad controlling pulse generation and feedback.

Kisspeptin-54 vs Kp-10

  • Why compare: Half-life, distribution, and receptor engagement differences across lengths/analogs.

Known Concerns (Context)

  • Tachyphylaxis risk: Continuous/very frequent exposure can blunt LH responses; patterning matters.
  • Axis sensitivity: Responses vary with sex-steroid milieu (e.g., estradiol/testosterone), energy availability, and stress.
  • General: For laboratory research use only; not for human consumption or therapeutic/veterinary use.

Specifications & Handling

  • Form: Lyophilized peptide powder (lot-coded)
  • Purity: ≥ 98–99% (HPLC/MS)
  • Storage: ≤ −20 °C (dry, dark). After reconstitution, refrigerate as protocol dictates.
  • Reconstitution: Prepare fresh; document solvent/vehicle, concentration, and time-to-assay; avoid repeated freeze–thaw.
  • Labeling: Tamper-evident; “Research Use Only”; variant (Kp-10/Kp-54), lot/SKU and expiration clearly displayed.

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

Kisspeptin (Kp-10 / Kp-54) Research Peptide | KISS1R (GPR54) Agonist | GnRH, LH/FSH & HPG Axis Studies

Keywords: Kisspeptin, Kp-10, KISS1, GPR54, KISS1R, GnRH stimulation, LH surge, KNDy neurons, reproductive axis research, Base Peptides.

View full details

Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
Keep Shopping