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IGF-1 LR3 1mg

IGF-1 LR3 1mg

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IGF-1 LR3 (Insulin-like Growth Factor 1 – Long R3)

Primary Function: Cell growth stimulation, muscle hypertrophy, anabolic enhancement
Research Use: Muscle growth, wound healing, neuroprotection, cellular regeneration
Molecular Formula: C400H625N111O115S9
CAS Number: 143045-27-6
Synonyms: Long R3 IGF-1, IGF-1 LR3, LR3 IGF-1


Description:
IGF-1 LR3 is a synthetic analog of human insulin-like growth factor 1 (IGF-1) engineered with an arginine substitution at position 3 and an extended N-terminal chain. These modifications drastically increase its half-life and reduce binding to IGF-binding proteins (IGFBPs), resulting in greater bioavailability and a more potent anabolic effect. IGF-1 LR3 is commonly studied for muscle hypertrophy, cell regeneration, neurogenesis, and tissue repair.


Mechanism of Action:

  • Binds to the IGF-1 receptor, stimulating PI3K/AKT and MAPK pathways
  • Promotes protein synthesis, cell proliferation, and muscle cell differentiation
  • Inhibits programmed cell death (apoptosis) in neural and muscle tissues
  • Enhances glucose uptake and nutrient transport

Key Research Areas:

  • Muscle growth and strength enhancement
  • Post-injury and surgical healing
  • Neuroprotective and cognitive research
  • Anti-aging and regenerative medicine

History of Discovery:
IGF-1 LR3 was designed by researchers aiming to overcome the short half-life and limited systemic effects of native IGF-1. By extending the chain and altering its third amino acid, scientists created a version with resistance to IGFBPs, enabling enhanced and sustained activation of anabolic signaling. It has since become one of the most researched analogs in muscle and tissue repair models.


Case Studies:

  1. Muscle Growth in GH-Deficient Rats (2000, J Endocrinol): IGF-1 LR3 promoted significant skeletal muscle hypertrophy and satellite cell activation independent of GH levels. [J Endocrinol. 2000;165(2):233–242.]
  2. Accelerated Wound Healing (2002, Wound Repair Regen): Application of IGF-1 LR3 improved epithelial regeneration and angiogenesis in burn wound models. [Wound Repair Regen. 2002;10(5):298–306.]
  3. Neural Protection (2005, Brain Res): IGF-1 LR3 preserved neuronal integrity and reduced apoptosis in models of spinal cord injury. [Brain Res. 2005;1052(1):87–97.]

Packaging Information:

  • Form: Lyophilized powder
  • Purity: ≥ 99%
  • Storage: Store at -20°C in a dry, dark environment
  • For research use only. Not for human or veterinary use.
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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.