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IGF-1 LR3

IGF-1 LR3

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$95.00
$95.00
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IGF-1 LR3 — Long Arg3 Insulin-Like Growth Factor 1 Analog

IGF-1 LR3 is a synthetic variant of natural Insulin‑Like Growth Factor‑1 (IGF-1), engineered to have **prolonged stability**, reduced binding to IGF-binding proteins, and enhanced anabolic signaling. It is used in research to study muscle growth, tissue regeneration, cell proliferation, metabolism, and repair-pathways. 

Identifiers
  • Synonym: IGF-1 Long R3 
  • CAS No: 143045-27-6 
  • Molecular weight (approx): ~9 kDa (≈ 9,000 Da) 
  • Sequence modifications: Arginine substitution at position 3 (Arg3) & 13-amino-acid N-terminal extension compared to native IGF-1.
How It Works (Plain English)
  • IGF-1 LR3 binds the IGF-1 receptor (IGF1R) triggering signaling cascades (PI3K/Akt, MAPK) which promote **cell growth, survival, and differentiation**. 
  • Because it binds less strongly to IGF-binding proteins (IGFBPs), it has higher free-fraction availability and longer action compared to IGF-1. 
  • This makes it a useful research tool for exploring **tissue regeneration, repair, anabolic biology, and metabolic signaling** in cells and in vivo models.
Why Researchers Use It
  • To study skeletal muscle repair, hypertrophy/hyperplasia, and regeneration after injury. 
  • To model connective-tissue, bone, cartilage and neuromuscular regeneration in preclinical systems. 
  • To explore metabolic endpoints: glucose uptake, amino-acid transport, fatty-acid metabolism and cell proliferation in tissue models. 

Key Studies — What Was Tested, What Changed, Why It 

Muscle growth & regeneration review
  • What was tested: Review of IGF-1 and analogues in skeletal muscle & regeneration models. 
  • What changed: IGF-1 (and analogues) seen to increase muscle-cell proliferation, differentiation and fiber formation in multiple models. 
  • Why it matters: Supports usage of IGF-1 LR3 in **research on repair and growth** rather than just hypertrophy. 
Bioavailability & potency of IGF-1 LR3
  • What was tested: Comparative binding-studies and potency analyses of IGF-1 vs IGF-1 LR3.
  • What changed: IGF-1 LR3 demonstrated greater potency and longer stability due to reduced IGFBP binding and extended half-life. 
  • Why it matters: Enables clearer signal in tissue-repair research where IGF-1 action may be masked by binding proteins. 

Potential Research Applications

Skeletal Muscle & Injury Repair

  • Myoblast proliferation, satellite-cell activation, fiber regeneration.
  • Muscle-atrophy models, immobilization recovery, aging muscle. 

Connective Tissue / Bone / Cartilage

  • Bone-mineralization, cartilage repair, tendon/ligament healing models. [oai_

Metabolic Signalling & Cell-Growth

  • Glucose uptake, amino-acid transport, fatty-acid oxidation, stem-cell culture support. [oai_

Synergistic Peptides (for Study Design)

CJC-1295 + Ipamorelin

  • Why pair: These peptides stimulate GH/IGF axis upstream, providing complementary mechanistic input.
  • Angle: GH-release (CJC + Ipamorelin) → IGF-1 LR3 downstream amplification; compare response and tissue outcomes.

MOTS-c

  • Why pair: Mitochondrial energy-metabolism peptide; combining with IGF-1 LR3 allows growth + energy readouts.

GHK-Cu

  • Why pair: ECM/trophic environment support; IGF-1 LR3 drives cell proliferation, GHK-Cu supports matrix foundation.

Known Concerns (Context)

  • Potent growth factor: Because IGF-1 LR3 is a strong anabolic/proliferative agent, pay close attention to off-target cell growth and tumour-risk models. 
  • Metabolic cross-talk: IGF-1R overlaps insulin receptor pathways—monitor glucose/insulin signalling if applicable. 
  • Research-use only: This product is not approved for therapeutic use. Proper labeling and compliance required.

Specifications & Handling

  • Form: Lyophilised recombinant peptide/protein (lot-coded) — verify salt/vehicle form.
  • Purity: Typically ≥ 98–99 % (HPLC/MS verified) for research-grade. 
  • Storage: ≤ −20 °C; protect from moisture/light; minimize freeze-thaw cycles.
  • In solution: Reconstitute with sterile buffer; document pH; consider carrier protein if low-bind surfaces needed. [oai_
  • Packaging: Tamper-evident; research-only labeling; disposal per institutional SOP.

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

IGF-1 LR3 Peptide Research | Long Arg3 Insulin-Like Growth Factor-1 Analog | Tissue Repair, Muscle & Metabolism Studies

Keywords: IGF-1 LR3 peptide, Long R3 IGF-1, IGF1R analog, tissue repair peptide, muscle regeneration, growth factor analog, IGF-1 binding proteins, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
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