Epithalon

Epithalon (Epitalon)

Primary Function: Telomerase activation, anti-aging, pineal regulation
Research Use: Longevity studies, melatonin modulation, cellular regeneration
Molecular Formula: C14H22N4O9
CAS Number: 307297-39-8
Synonyms: Epitalon, Epithalamin, Ala-Glu-Asp-Gly

Description:
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from a naturally occurring extract of the pineal gland called Epithalamin. It has been extensively studied for its ability to stimulate telomerase, extend cellular lifespan, and regulate circadian rhythm through increased melatonin production. Epithalon is a key compound in anti-aging and regenerative medicine research, with evidence suggesting it may delay age-related decline, improve immune function, and enhance oxidative stress resistance.

Mechanism of Action:

• Activates telomerase enzyme, supporting chromosomal stability
• Increases melatonin secretion by stimulating pineal activity
• Enhances antioxidant enzyme activity and DNA repair
• Modulates hypothalamic and endocrine signaling in aging models

Key Research Areas:

• Telomere maintenance and longevity studies
• Sleep quality and circadian regulation
• Immune system support in aging models
• Antioxidant activity and DNA stability

History of Discovery:
Epithalon was developed by Professor Vladimir Khavinson of the St. Petersburg Institute of Bioregulation and Gerontology in the 1980s. It was originally isolated from the pineal gland and then synthesized to mimic the active component. Since then, it has been the subject of more than 100 studies in the context of biogerontology, making it one of the most respected bioregulator peptides in aging research.

Case Studies:

1. Telomere Length Extension (2003, Bull Exp Biol Med): Epithalon activated telomerase and significantly extended telomere length in aging lymphocytes. [Bull Exp Biol Med. 2003;135(5):511–514.]
2. Increased Lifespan in Animal Models (2000, Neuroendocrinol Lett): Rodents treated with Epithalon experienced up to 30% increased lifespan and reduced tumor incidence. [Neuroendocrinol Lett. 2000;21(2):163–176.]
3. Improved Sleep & Melatonin in Older Adults (1998, Ann N Y Acad Sci): Clinical study showed enhanced melatonin rhythms and improved subjective sleep quality. [Ann N Y Acad Sci. 1998;854:448–457.]

Packaging Information:

• Form: Lyophilized powder
• Purity: ≥ 99%
• For research use only. Not for human or veterinary use.