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DSIP

DSIP

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$39.99
$39.99
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DSIP — Delta Sleep-Inducing Peptide (Nonapeptide)

DSIP is a naturally occurring nonapeptide historically linked with sleep-architecture research. It’s used in laboratory settings to explore sleep regulation, stress-axis modulation, and neuroendocrine signaling in controlled models.

Identifiers
  • Aliases: Delta Sleep-Inducing Peptide
  • CAS: 62568-57-4
  • Sequence (9 aa): Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
  • Approx. MW: ~849.9 Da (salt/form dependent)
How It Works (Plain English)
  • DSIP has been studied as a modulator of sleep homeostasis and slow-wave (delta) activity in select models.
  • Evidence suggests cross-talk with GABAergic, glutamatergic (NMDA), and HPA-axis signaling, but the primary receptor target remains unresolved.
  • Research also explores interactions with neuroendocrine peptides and stress markers (e.g., CRH/ACTH contexts).
Why Laboratories Use It
  • To examine sleep architecture and EEG delta-power changes in animal and in-vitro systems.
  • To study stress-response modulation (HPA-axis markers, cortisol/ACTH paradigms).
  • To investigate pain/antinociception and autonomic tone in translational models.

Key Study Themes — What’s Typically Tested

Sleep & EEG endpoints
  • What’s tested: Changes in slow-wave sleep surrogates (delta power), sleep latency, and REM/NREM distribution after DSIP exposure.
  • What’s observed: Model-dependent modulation of delta activity; effects can vary with dose, route, and species.
  • Why it matters: Useful tool for dissecting sleep-homeostasis mechanisms and peptide-based neuromodulation.
Stress-axis & autonomic readouts
  • What’s tested: HPA-axis hormones (CRH, ACTH, cortisol/corticosterone), HRV and autonomic markers under challenge.
  • What’s observed: Context-dependent effects on stress markers; labs often pair with behavioral assays for interpretation.
  • Why it matters: Helps map peptide influence on stress resilience and neuroendocrine balance.

Potential Research Applications

Sleep & Circadian Biology

  • EEG/EMG sleep scoring, delta power, circadian phase markers
  • Interactions with melatonin/pineal, GABA/glutamate signaling

Stress & Neuroendocrine

  • HPA-axis reactivity, ACTH/cortisol profiling
  • Behavioral stress assays (e.g., EPM/open field) where appropriate

Pain & Autonomic Tone

  • Antinociception, HRV, baroreflex sensitivity under peptide challenge

Synergistic / Comparator Peptides

Epitalon

  • Why pair: Pineal/circadian context; compare or combine for sleep and ageing endpoints.

Selank / Semax

  • Why pair: Neuro-trophic/anti-anxiety context that can complement stress/sleep designs.

Oxytocin (comparator)

  • Why compare: Social/affiliative neuropeptide with sleep-adjacent effects in some paradigms.

Design Notes

  • Pre-register dosing time relative to lights-on/off—sleep outcomes are highly phase-sensitive.
  • Control for handling stress; include vehicle and time-of-day controls.

Known Concerns (Context)

  • Mechanism uncertainty: Primary receptor/target not definitively established; effects can be model- and dose-dependent.
  • Mixed literature: Positive and null findings exist; study design and species differences drive variability.
  • General: For laboratory research use only; not for human consumption or therapeutic use.

Specifications & Handling

  • Form: Lyophilized peptide powder (lot-coded)
  • Purity: ≥ 98–99% (HPLC/MS verified)
  • Storage: ≤ −20 °C; protect from light/moisture; minimize freeze–thaw
  • In solution: Reconstitute with sterile buffer; document vehicle, pH, and time-to-assay
  • Packaging: Tamper-evident; research-only labeling

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

DSIP Peptide Research | Delta Sleep-Inducing Peptide | Sleep Architecture, HPA-Axis & Neuroendocrine Studies

Keywords: DSIP peptide, delta sleep-inducing peptide, nonapeptide sleep research, HPA-axis modulation, neuroendocrine peptide, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
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