DSIP

DSIP (Delta Sleep-Inducing Peptide)

Primary Function: Sleep regulation, stress response modulation, neuroendocrine balance
Research Use: Insomnia models, circadian rhythm regulation, neuroprotection, pain modulation
Molecular Formula: C35H48N10O15
CAS Number: 62568-57-4
Synonyms: Delta Sleep Peptide, DSIP, Δ-Sleep-Inducing Peptide

Description:
DSIP is a naturally occurring neuropeptide that was first isolated from the brain tissue of rabbits during sleep studies. It has shown profound influence over sleep architecture, particularly by promoting slow-wave (deep) sleep without acting as a sedative or hypnotic. DSIP is also being studied for its stress-reducing, antioxidant, and neuroendocrine regulatory effects, including its role in reducing cortisol levels and improving HPA axis function.

Mechanism of Action:

• Modulates activity in the hypothalamus and pituitary, influencing sleep cycles
• Promotes slow-wave (deep) sleep and regulates circadian rhythm
• Reduces ACTH and cortisol secretion under stress
• May enhance mitochondrial activity and neuroprotection under oxidative stress

Key Research Areas:

• Insomnia and circadian rhythm disorders
• Anxiety and stress regulation
• Opioid withdrawal and pain modulation
• Neurodegeneration and oxidative stress resistance

History of Discovery:
DSIP was discovered in 1974 by Swiss researchers Schoenenberger and Monnier while studying sleep-regulating substances in rabbit cerebrospinal fluid. It was later synthesized and studied extensively throughout Europe and Russia for its non-habit-forming, restorative properties. Unlike traditional sedatives, DSIP has shown unique effects on natural sleep induction and hormone regulation.

Case Studies:

1. Improved Sleep Architecture (1984, Pharmacol Biochem Behav): DSIP administration improved sleep latency and increased delta-wave sleep in clinical insomnia models. [Pharmacol Biochem Behav. 1984;21(3):457–461.]
2. Stress Hormone Reduction (1992, Acta Endocrinol): DSIP lowered plasma ACTH and cortisol levels in stressed subjects without impairing cognitive function. [Acta Endocrinol. 1992;127(5):444–450.]
3. Pain Threshold Modulation (1981, Brain Res): DSIP increased pain tolerance and reduced opioid dependence in rodent withdrawal models. [Brain Res. 1981;213(2):425–433.]

Packaging Information:

• Form: Lyophilized powder
• Purity: ≥ 99%
• For research use only. Not for human or veterinary use.