CJC with DAC
CJC with DAC
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CJC-1295 with DAC
Primary Function: Long-acting growth hormone-releasing hormone analog
Research Use: GH pulsatility, anti-aging, muscle gain, fat loss
Molecular Formula: C165H271N47O46
CAS Number: 863288-34-0
Synonyms: Modified GRF 1-29 with DAC, CJC-1295-DAC, Drug Affinity Complex CJC
Description:
CJC-1295 with DAC is a synthetic analog of growth hormone-releasing hormone (GHRH) designed to significantly extend the half-life of GHRH activity in vivo. DAC stands for Drug Affinity Complex, a molecular addition that allows CJC-1295 to bind to serum albumin, resulting in a prolonged duration of action—up to 7–10 days after a single dose. This makes it an attractive research compound for exploring sustained GH elevation, improved body composition, and recovery support.
Mechanism of Action:
- Binds to GHRH receptors in the pituitary gland
- Stimulates natural growth hormone release over extended duration
- DAC binds to albumin, preventing enzymatic breakdown
- Increases downstream IGF-1 levels through sustained GH pulses
Key Research Areas:
- Anti-aging and longevity research
- Lean muscle gain and fat metabolism
- GH deficiency and hormonal balance
- Wound healing, recovery, and sleep enhancement
History of Discovery:
CJC-1295 was developed by ConjuChem Biotechnologies in the early 2000s. The addition of the Drug Affinity Complex (DAC) to the GRF 1-29 peptide chain resulted in dramatically increased half-life and bioavailability. This modification enabled researchers to study the effects of prolonged GH elevation from fewer administrations, making it ideal for long-term hormone optimization studies.
Case Studies:
- Sustained IGF-1 Elevation in Healthy Adults (2006, Clinical Endocrinology): A single dose of CJC-1295 with DAC increased IGF-1 levels for up to 6 days post-administration with minimal side effects. [Clin Endocrinol (Oxf). 2006;64(2):169–178.]
- Fat Loss and Muscle Preservation in Obese Subjects (2009, J Clin Pharmacol): Weekly dosing led to improved lean-to-fat ratio over 12 weeks in obese adult males. [J Clin Pharmacol. 2009;49(6):681–688.]
- Enhanced Recovery in Post-Surgical Animal Models (2012, Peptides): Subjects administered CJC-1295 with DAC exhibited faster wound healing and improved tissue regeneration. [Peptides. 2012;33(2):265–273.]
Packaging Information:
- Form: Lyophilized powder
- Purity: ≥ 99%
- Storage: Store at -20°C in a dry, dark environment
- For research use only. Not for human or veterinary use.


