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Ibutamoren MK-677

Ibutamoren MK-677

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$60.00
$60.00
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MK-677 (Ibutamoren) — Oral Ghrelin (GHSR-1a) Agonist / GH Secretagogue

MK-677 (USAN: Ibutamoren) is an orally active growth-hormone secretagogue that stimulates the ghrelin receptor (GHSR-1a). It’s used in research to study GH/IGF-1 axis physiology, body-composition, sleep architecture, and metabolic endpoints.

Identifiers
  • Common names: MK-677; Ibutamoren; L-163,191
  • CAS: 159752-10-0 (mesylate forms may differ)
  • Class: Non-peptide ghrelin receptor agonist (GHSR-1a)
  • Approx. half-life: ~24 hours (model-dependent)
How It Works (Plain English)
  • MK-677 binds GHSR-1a in the pituitary/hypothalamus → increases intracellular Ca2+ → triggers pulsatile GH release.
  • Rising GH typically leads to higher hepatic IGF-1 levels and downstream anabolic/repair signaling.
  • Because it’s oral and long-acting, it’s useful for studying **sustained** GH/IGF-1 exposure compared with short-acting GHRPs.
Why Researchers Use It
  • To model GH/IGF-1 dynamics in adult and older cohorts.
  • To examine fat-free mass, nitrogen balance, and protein-turnover endpoints.
  • To study sleep/EEG changes (slow-wave sleep) related to ghrelin/GH signaling.

Key Study Themes — What’s Typically Observed

GH & IGF-1 Increases
  • What’s tested: Serial GH sampling; IGF-1 and IGFBP-3 before/after MK-677 exposure.
  • Observed: Robust GH pulses and sustained IGF-1 elevations with daily oral administration.
  • Why it matters: Useful for endocrine-axis mapping and anabolic/repair research models.
Body-Composition / Protein Turnover
  • What’s tested: Lean mass, nitrogen balance, muscle protein synthesis markers.
  • Observed: Increases in fat-free mass with mixed effects on strength depending on design/duration.
  • Why it matters: Supports studies on sarcopenia, recovery, and anabolic balance.
Sleep & Appetite
  • What’s tested: EEG/EMG scoring (slow-wave sleep), appetite/meal initiation.
  • Observed: ↑ slow-wave sleep metrics in some designs; orexigenic (appetite-increasing) effects are common.
  • Design note: Appetite shifts can confound body-comp outcomes—control diet tightly.

Potential Research Applications

Endocrine Physiology

  • GH pulse profiling, IGF-1 kinetics, feedback/deconvolution analyses

Aging / Sarcopenia Models

  • Lean-mass maintenance, nitrogen balance, functional endpoints

Sleep & Recovery

  • Slow-wave sleep measures, recovery paradigms, circadian interactions

Synergistic / Comparator Compounds

CJC-1295 (±DAC) / Ipamorelin

  • Why pair: GHRH-pathway or selective GHS secretagogues can fine-tune GH pulse shape vs MK-677’s sustained exposure.

GHRP-2 / GHRP-6

  • Why compare: Short-acting ghrelin mimetics vs long-acting oral MK-677 for endocrine selectivity and appetite effects.

Tesamorelin (comparator)

  • Why compare: GHRH analogue with distinct lipolytic/visceral-fat effects vs GHS agonism.

Design Notes

  • Pre-specify diet/activity; include PRL/cortisol panels if selectivity is a question.
  • Schedule sampling to capture both acute pulses and steady-state IGF-1.

Known Concerns (Context)

  • Appetite & edema: Orexigenic effects and fluid retention are reported in some models; track weight and edema indices.
  • Glucose/insulin: Some studies note modest insulin-sensitivity changes—monitor metabolic panels as appropriate.
  • Endocrine breadth: Generally minimal effect on cortisol/prolactin vs classic GHRPs, but verify in your design.
  • General: For laboratory research use only; not for human consumption or therapeutic use.

Specifications & Handling

  • Form: Small-molecule solid (lot-coded); specify base vs mesylate on label
  • Purity: Research-grade (HPLC/MS, typically ≥98%)
  • Storage: Cool, dry; protect from light/moisture
  • In solution: Commonly dissolved in DMSO/ethanol for in-vitro; record solvent %, pH, time-to-assay
  • Labeling: Tamper-evident; research-only; lot/SKU and expiration clearly displayed

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

MK-677 (Ibutamoren) Research Compound | Oral Ghrelin (GHSR-1a) Agonist | GH/IGF-1, Body-Composition & Sleep Studies

Keywords: MK-677, Ibutamoren, ghrelin receptor agonist, GHSR-1a, growth hormone secretagogue, IGF-1, lean mass, slow-wave sleep, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
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