Glutathione

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$199.00

Sale Sold out

Shipping calculated at checkout.

Volume 1500

Quantity

Glutathione (GSH) — γ-L-Glu-L-Cys-Gly Tripeptide • Reduced Form

Glutathione (GSH) is a ubiquitous intracellular antioxidant tripeptide—γ-glutamyl-cysteinyl-glycine. It maintains cellular redox balance, supports detoxification via conjugation chemistry, and fuels enzymatic defenses such as glutathione peroxidase and glutathione S-transferases.

Identifiers

Synonyms: L-Glutathione (reduced); GSH
CAS No.: 70-18-8
Formula / MW: C₁₀H₁₇N₃O₆S • ~307.32 g·mol⁻¹
Class: Endogenous antioxidant; phase-II conjugate donor

How It Works (Plain English)

Redox buffer: GSH neutralizes peroxides (via glutathione peroxidase), forming GSSG which is recycled back to GSH by glutathione reductase using NADPH.
Detox chemistry: Conjugates electrophiles/xenobiotics via glutathione S-transferases, aiding cellular clearance.
Protein protection: Maintains thiol status of proteins; the GSH:GSSG ratio is a standard readout of oxidative stress.

Why Researchers Use It

To modulate/measure oxidative stress and redox signaling pathways.
To study detoxification capacity and xenobiotic metabolism.
To probe immune function, mitochondrial resilience, and thiol-based signaling.

Key Study Themes — What’s Typically Observed

Oxidative Stress & Redox Biology

Endpoints: GSH, GSSG, GSH:GSSG ratio, GPx/GR activity, ROS, lipid peroxidation.
Typical findings: Higher intracellular GSH and favorable GSH:GSSG ratios align with improved resistance to oxidative insults (model-dependent).

Detoxification & Conjugation

Endpoints: GST activity, adduct formation/clearance, Phase-II metabolism panels.
Typical findings: Enhanced clearance of reactive electrophiles and reduced protein/DNA adduct burden in vitro/in vivo models.

Mitochondrial & Immune Readouts

Endpoints: Mitochondrial membrane potential, ATP, cytokines, T-cell function, thiol redox.
Typical findings: Improved mitochondrial redox tone and modulation of inflammatory markers (design-dependent).

Potential Research Applications

Redox & Aging Biology

Senescence/ROS assays, proteome thiol protection, lipid peroxidation models.

Detox & Xenobiotics

Phase-II metabolism, electrophile stress, environmental toxicology.

Mitochondrial & Immune Health

NADPH coupling, cytokine modulation, infection/inflammation stress tests.

Synergistic / Comparator Compounds

N-Acetyl-L-Cysteine (NAC)

Why pair: Cysteine donor for endogenous GSH synthesis; complements direct GSH provision.

Vitamin C & Alpha-Lipoic Acid

Why pair: Antioxidant network recycling (ascorbate ↔ glutathione; lipoic/di-hydrolipoic redox couple).

Glycine / Serine

Why pair: Substrates for GSH synthesis and one-carbon metabolism interplay.

What’s in the Vial (Editable)

Active	Per Vial	Grade / Purity
Glutathione (Reduced, GSH)	500 mg (set per SKU)	Research-grade, ≥ 98–99% (HPLC/MS)
Appearance	White to off-white powder; sulfurous odor possible (cysteine thiol)
Solubility	Water-soluble; prepare fresh solution for lab use

Specifications & Handling

Form: Lyophilized powder or capsules (lot-coded)
Storage: ≤ −20 °C long-term; protect from light and metal contamination
Stability: Oxidizes to GSSG with heat/air/light; consider inert atmosphere and chelators (e.g., EDTA) in sensitive assays

Reconstitution (lab use): Use freshly prepared, pH-buffered aqueous media (near neutral); minimize repeated freeze–thaw.
Labeling: Research Use Only; CAS/lot/SKU and expiration clearly displayed.

Known Concerns (Context)

Chemical lability: Susceptible to oxidation; handle quickly, cold, and protected from light/metals.
Assay interference: Thiol chemistry may affect metal-dependent enzymes and redox-sensitive dyes—validate controls.
General: For laboratory research use only; not for human consumption or therapeutic/veterinary use.

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

Glutathione (GSH) Research | Reduced Glutathione Tripeptide | Antioxidant, Detox & Redox Biology Studies

Keywords: glutathione, GSH, reduced glutathione, γ-L-Glu-L-Cys-Gly, antioxidant, GSSG, glutathione peroxidase, detoxification, Base Peptides.

View full details

Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.

Keep Shopping