1 5

GHK-CU Copper Peptide

GHK-CU Copper Peptide

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$75.00
$75.00
Sale Sold out
Shipping calculated at checkout.
Product Options

GHK-Cu — Copper Tripeptide Complex

GHK-Cu is a naturally occurring copper-binding peptide made of three amino acids: glycine, histidine, and lysine. In research, it’s valued for its role in skin and tissue biology, where it influences cell signaling, collagen production, and wound-healing markers.

Identifiers
  • CAS: 89030-95-5 (GHK-Cu)
  • PubChem CID: 378611
  • Formula / MW: C14H24N6O4·Cu · ≈ 404 Da
  • Sequence: Gly-His-Lys (GHK)
How It Works (Plain English)
  • GHK is a small signal peptide that binds copper ions—an essential mineral for tissue renewal and enzyme function.
  • This binding activates a cascade of cell messages linked to collagen and elastin production.
  • It also helps regulate inflammation and antioxidant activity in local tissue environments.
Why Researchers Use It
  • To study cell-matrix communication and regeneration.
  • To examine the impact of trace-metal balance (especially copper) in cell cultures.
  • To investigate skin, wound, or ECM remodeling pathways in vitro and in vivo.

Key Studies — What Was Tested, What Changed, Why It Matters

Skin-repair and wound-healing models
  • What was tested: Cell-culture and animal skin-wound models comparing copper-bound GHK vs controls.
  • What changed: Enhanced expression of collagen, integrins, and growth factors associated with skin regeneration. Improved wound closure speed and smoother collagen organization were often observed.
  • Why it matters: Provides a molecular link between copper homeostasis and the skin’s ability to rebuild structure after injury.
Anti-oxidant and anti-inflammatory pathways
  • What was tested: Oxidative-stress assays in fibroblasts and keratinocytes.
  • What changed: Increased production of protective enzymes like superoxide dismutase (SOD) and catalase; reduced inflammatory markers such as IL-6 in stress conditions.
  • Why it matters: These findings suggest GHK-Cu can serve as a model molecule for studying cell protection and aging pathways.
Hair-follicle and dermal remodeling research
  • What was tested: Topical and cell-based studies focusing on hair-follicle signaling and dermal fibroblast activity.
  • What changed: Up-regulation of genes involved in follicle growth and dermal repair, plus better alignment of collagen fibers under microscopy.
  • Why it matters: Shows GHK-Cu’s broader relevance for skin-biology and regenerative-cosmetic research fields.

Potential Research Applications

Skin Biology & Regeneration

  • Collagen/elastin synthesis markers
  • Keratinocyte-fibroblast co-culture models

Trace-Metal & Enzyme Studies

  • Copper-dependent enzyme regulation (SOD, lysyl oxidase)
  • Metal-transport and chelation assays

Inflammation & Oxidative Stress

  • Reactive-oxygen species (ROS) measurement
  • Cytokine and gene-expression analysis

Synergistic Peptides (for Study Design)

BPC-157

  • Why pair: Complements GHK-Cu in tissue-healing and angiogenesis research models.
  • Angle: Co-culture or sequential application to study combined effects on microcirculation and matrix organization.

Thymosin-β4 / TB-500

  • Why pair: Often used to assess cell migration and actin remodeling alongside copper-peptide cues.
  • Angle: Compare timing and gene-expression panels between early and late response peptides.

Epithalon / Epitalon

  • Why pair: Used for cell longevity and telomere-related pathways, complementing GHK-Cu’s rejuvenation signaling studies.
  • Angle: Combined cell-aging assays examining oxidative stress and telomere-length preservation.

Design Notes

  • Define copper concentration precisely; small differences alter results.
  • Track timing—GHK vs GHK-Cu kinetics differ in culture.
  • Maintain metal-free controls to isolate copper’s contribution.

Known Concerns (Context)

  • Metal variability: Results depend on copper source and buffer composition—document both carefully.
  • Assay sensitivity: Some readouts respond to even trace metals; replicate under controlled conditions.
  • Context: GHK-Cu is a research molecule, not a cosmetic or medical active ingredient.

Follow institutional SOPs and material-handling guidance for metal-bound peptides.

Specifications & Handling

  • Form: Lyophilized powder (lot-coded)
  • Purity: ≥ 99% (HPLC/MS verified)
  • Storage: ≤ −20 °C; protect from light/moisture
  • In solution: Aliquot and store frozen; avoid repeat freeze–thaw
  • Additives: None unless specified per lot
  • Packaging: Tamper-evident, research-only labeling

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

GHK-Cu Peptide Research | Copper Tripeptide | Skin Regeneration & Antioxidant Pathways

Keywords: GHK-Cu peptide, copper tripeptide, collagen synthesis research, antioxidant pathways, wound-healing models, Base Peptides.

View full details

Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
Keep Shopping