SLU-PP-332

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

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SLU-PP-332 — Pan-ERR Agonist (Exercise-Mimetic Tool Compound)

SLU-PP-332 is a small-molecule agonist of the estrogen-related receptors (ERRα/β/γ), with greatest potency at ERRα (EC₅₀ ≈ 98 nM). It is widely used to probe mitochondrial biogenesis, oxidative metabolism, and “exercise-mimetic” programs in preclinical models.

Identifiers

Other name: 4-Hydroxy-N-[(Z)-naphthalen-2-ylmethylideneamino]benzamide
CAS: 303760-60-3 • PubChem CID: 5404083
Formula: C₁₈H₁₄N₂O₂ • Core class: ERR agonist (pan), strongest at ERRα

How It Works (Plain English)

Activates nuclear receptors ERRα/β/γ, partnering with co-activators like PGC-1α to up-regulate genes for mitochondrial biogenesis, OXPHOS, and fat oxidation.
Functionally mimics endurance-training signals (↑ energy expenditure, ↑ oxidative capacity) in animal and cell models.

Why Researchers Use It

To map exercise-responsive transcription and mitochondrial programs in muscle/adipose models.
To study metabolic syndrome/obesity pathways and insulin sensitivity in diet-induced models.
To explore aging kidney/cardiac mitochondrial dysfunction and inflammation.

Key Studies — What Was Tested, What Changed, Why It Matters

Exercise-mimetic effects (preclinical)

What was tested: ERR agonist activity of SLU-PP-332 and downstream endurance-like adaptations in mice.
What changed: ↑ energy expenditure; improved fat metabolism; enhanced running/endurance capacity without increasing food intake.
Why it matters: Useful tool for dissecting exercise-responsive metabolic programs without confounding activity changes.

Metabolic syndrome/obesity models

What was tested: ERR pan-agonism in diet-induced obesity/metabolic syndrome models.
What changed: ↓ adiposity, improved glucose tolerance/insulin sensitivity, better lipid handling. [oa
Why it matters: Positions ERR activation as a tractable node for obesity/metabolic disease research.

Aging kidney & mitochondrial inflammation

What was tested: SLU-PP-332 in aging-kidney models with mitophagy/Inflammation endpoints.
What changed: Reversed mitochondrial dysfunction and reduced inflammatory signaling in aged mice.
Why it matters: Extends ERR agonism beyond adipose/muscle to organ aging biology.

Potential Research Applications

Mitochondria & Bioenergetics

TFAM/NRF1/NRF2, OXPHOS panels; mitochondrial copy-number & respiration assays

Metabolic Disease Models

Diet-induced obesity, fatty-acid oxidation, glucose tolerance & insulin sensitivity

Healthy Aging / Organ Function

Kidney/cardiac mitochondrial dysfunction; inflammatory signaling resolution

Synergistic / Comparator Agents

MOTS-c

Why pair: Mitochondrial peptide; combine with ERR agonism to study bioenergetics + metabolic resilience.

AICAR or AMPK Activators (comparator)

Why compare: Distinguish AMPK-first signaling from nuclear-receptor-first (ERR) programs.

GLP-1 / Cagrilintide (comparator)

Why compare: Appetite-centric vs exercise-mimetic mechanisms in weight-loss research.

Known Concerns (Context)

Tool compound status: Evidence is preclinical; human safety/PK not established. Design studies conservatively.
Nuclear receptor breadth: Pan-ERR agonism may yield off-target transcriptional programs; include broad transcriptomics where possible.
General: For laboratory research use only; not for human consumption or therapeutic use.

Specifications & Handling

Form: Small-molecule research compound (solid)
Purity: Research-grade (HPLC/MS)
Storage: Cool, dry; protect from light/moisture; verify lot-specific guidance

In solution: Typically soluble in DMSO; record solvent %, pH, and time-to-assay; minimize freeze–thaw
Labeling: Tamper-evident; “research use only”; CAS and lot on label

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

SLU-PP-332 Research Compound | Pan-ERR (ERRα/β/γ) Agonist | Exercise-Mimetic, Mitochondrial & Metabolic Studies

Keywords: SLU-PP-332, ERRα agonist, exercise mimetic, mitochondrial biogenesis, oxidative phosphorylation, metabolic syndrome research, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.

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