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Sermorelin

Sermorelin

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

$50.00
$50.00
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Sermorelin — Growth Hormone Releasing Hormone (GRF 1-29) Analogue

Sermorelin is a short synthetic analogue of Growth Hormone Releasing Hormone (GHRH) consisting of the first 29 amino acids of the full 44-amino-acid sequence. It’s widely used in research to study growth hormone (GH) secretion, pituitary responsiveness, and endocrine signaling patterns.

Identifiers
  • CAS: 86168-78-7
  • PubChem CID: 16132353
  • Formula / MW: C149H246N44O42S · ≈ 3357 Da
  • Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
How It Works (Plain English)
  • Sermorelin acts as a GHRH receptor agonist, signaling the pituitary to release natural GH in short, rhythmic bursts.
  • It helps researchers study GH pulse timing, amplitude, and downstream IGF-1 signaling.
  • Because it’s short-acting, it’s ideal for examining controlled, physiologic GH pulses rather than sustained exposure.
Why Researchers Use It
  • To evaluate pituitary GH reserve and responsiveness in animal or human models.
  • To compare short-acting vs long-acting GHRH analogues like CJC-1295.
  • To explore feedback mechanisms within the GH/IGF-1 axis.

Key Studies — What Was Tested, What Changed, Why It Matters

GH pulse induction and pituitary responsiveness
  • What was tested: Sermorelin’s ability to elicit GH release across doses and timing intervals.
  • What changed: Clear, short-lived GH pulses that closely mimic natural secretion patterns were recorded.
  • Why it matters: Provides a reference model for endogenous GH rhythm studies and GH/IGF-1 relationship tracking.
Comparative pharmacokinetics with CJC-1295
  • What was tested: Half-life and GH/IGF-1 response curves compared between Sermorelin and CJC-1295 (DAC).
  • What changed: Sermorelin produced faster, shorter peaks, while CJC-1295 showed prolonged elevation due to albumin binding.
  • Why it matters: Helps define pulse vs sustained-release dynamics in GH-axis research models.
Feedback and endocrine coordination studies
  • What was tested: GH and IGF-1 response with repeated Sermorelin pulses and time-separated sampling.
  • What changed: Predictable oscillation of GH peaks with minimal suppression or receptor fatigue over time.
  • Why it matters: Reinforces Sermorelin’s role as a naturalistic GH secretagogue model.

Potential Research Applications

Endocrine Axis Research

  • GH secretion dynamics and IGF-1 feedback
  • Receptor activation and pituitary response mapping

Comparative Pharmacology

  • Short-acting (Sermorelin) vs long-acting (CJC-1295) GHRH analogues
  • GH pulse frequency and amplitude modeling

Endocrine Recovery Models

  • Testing feedback loops within GH/IGF-1 systems
  • Short-term pituitary responsiveness assays

Synergistic Peptides (for Study Design)

Ipamorelin

  • Why pair: Activates the ghrelin receptor (GHSR), working synergistically with Sermorelin’s GHRH pathway.
  • Angle: Dual-pathway GH stimulation for studying amplitude + frequency synergy.

CJC-1295 (with DAC)

  • Why pair: Long-acting GHRH analogue for side-by-side or sequential studies.
  • Angle: Compare short vs sustained GH signaling and downstream IGF-1 changes.

Tesamorelin

  • Why pair: Shares receptor target but with enhanced stability and selectivity.
  • Angle: Advanced comparisons of efficacy, duration, and lipid metabolism markers.

Design Notes

  • Ensure consistent GH sampling windows (15–60 min post-stimulus).
  • Document vehicle, pH, and temperature—Sermorelin is hydrolysis-sensitive.
  • Isolate GH pulse frequency from amplitude when analyzing output.

Known Concerns (Context)

  • Short half-life: Requires precise timing for sample collection to capture GH peaks.
  • Stability: Peptide is moisture- and temperature-sensitive; handle under cold, dry conditions.
  • General: Research use only; not intended for therapeutic or human consumption purposes.

Follow standard endocrine assay handling protocols to ensure reproducibility.

Specifications & Handling

  • Form: Lyophilized powder (lot-coded)
  • Purity: ≥ 99% (HPLC/MS verified)
  • Storage: ≤ −20 °C; protect from light/moisture
  • In solution: Aliquot promptly; avoid repeat freeze–thaw
  • Additives: None unless specified per lot
  • Packaging: Tamper-evident; research-only labeling

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

Sermorelin Peptide Research | GRF 1-29 Analogue | Growth Hormone Secretagogue | GH/IGF-1 Studies

Keywords: Sermorelin peptide, GRF 1-29, GHRH analogue, growth hormone release, pituitary function, IGF-1 response, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.
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