Sermorelin

Sermorelin

Primary Function: Stimulates natural growth hormone release
Research Use: Anti-aging, GH deficiency models, lean mass preservation
Molecular Formula: C149H246N44O42S
CAS Number: 86168-78-7
Synonyms: Geref, GRF 1-29, Sermorelin acetate

Description:
Sermorelin is a synthetic analog of the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH). It is the shortest fully functional fragment capable of stimulating growth hormone secretion from the pituitary. Sermorelin is widely studied in age-related GH decline, body composition optimization, and endocrine health.

Mechanism of Action:

• Binds to GHRH receptors in the anterior pituitary
• Triggers natural secretion of growth hormone
• Increases downstream IGF-1 production
• Does not suppress natural GH feedback mechanisms

Key Research Areas:

• GH deficiency models and pediatric endocrinology
• Anti-aging and rejuvenation studies
• Lean muscle maintenance and fat reduction
• Sleep quality and tissue repair

History of Discovery:
Sermorelin was originally developed by Serono Laboratories in the 1980s as a treatment for growth hormone deficiency in children. It was approved by the FDA under the trade name Geref. Its structure (GRF 1-29) mimics the bioactive portion of endogenous GHRH and became a cornerstone in peptide research for age-related decline and performance optimization.

Case Studies:

1. Improved Growth Velocity in Pediatric GH Deficiency (1990, J Clin Endocrinol Metab): Children treated with Sermorelin showed significant increases in height velocity over 6 months compared to baseline. [J Clin Endocrinol Metab. 1990;71(5):1157–1162.]
2. Increased IGF-1 and Lean Mass in Adults (2001, Growth Horm IGF Res): Adults receiving Sermorelin exhibited increased IGF-1 levels and improvements in body composition. [Growth Horm IGF Res. 2001;11(5):261–267.]
3. Sleep-Related GH Pulsatility Enhancement (2003, Neuroendocrinology Letters): Sermorelin restored nighttime GH secretion patterns in older subjects, improving sleep quality and circadian regulation. [Neuroendocrinol Lett. 2003;24(3-4):195–201.]

Packaging Information:

• Form: Lyophilized powder
• Purity: ≥ 99%
• For research use only. Not for human or veterinary use.