Selank & Semax Blend

Selank & Semax Peptide Blend

Primary Function: Cognitive enhancement, anxiety reduction, neuroprotection
Research Use: Nootropic synergy, stress resilience, neuroinflammation modulation, post-stroke recovery
Molecular Formulas:

• Selank: C33H57N11O9
• Semax: C37H51N9O10
  CAS Numbers:
• Selank: 129954-34-3
• Semax: 80714-61-0

Description:
The Selank & Semax peptide blend combines two well-characterized neuroactive peptides that function synergistically to support cognitive performance, emotional balance, and neuroimmune modulation.

• Selank is a synthetic analog of tuftsin, exhibiting anxiolytic and immunomodulatory effects through interaction with GABA and serotonin systems.
• Semax, a heptapeptide derived from ACTH(4-10), is a potent neurotrophic agent known for enhancing BDNF expression, dopamine signaling, and cognitive restoration following neurological insult.

Mechanism of Action:

• Selank
  • Modulates GABAergic and serotonergic neurotransmission
  • Reduces pro-inflammatory cytokines and stabilizes immune function
  • Enhances stress resilience without sedation
• Semax
  • Stimulates production of BDNF, NGF, and dopamine in the hippocampus
  • Promotes neurogenesis and synaptic plasticity
  • Protects neurons from oxidative and ischemic damage

Key Research Areas:

• Memory and learning enhancement
• Stress-induced cognitive decline
• Anxiety and mood disorders
• Stroke recovery and ischemic brain injury
• ADHD and executive function modulation

History of Discovery:
Both peptides were developed in Russia in the 1990s by the Institute of Molecular Genetics and Institute of Pharmacology, Russian Academy of Sciences.

• Selank was synthesized to replicate the anxiolytic effects of tuftsin, tailored for non-sedative central nervous system activity.
• Semax was designed as a neuroprotective ACTH analog with longer-lasting effects and targeted gene activation for neuroregeneration.

Case Studies:

1. Stress-Induced Cognitive Decline (2008, Neurosci Behav Physiol): Mice treated with a Selank and Semax combination showed superior learning performance and memory retention under psychological stress. [Neurosci Behav Physiol. 2008;38(3):289–293.]
2. Stroke Recovery (2011, Bull Exp Biol Med): Semax–Selank blend improved behavioral scores and neuroplastic markers in rats post-cerebral ischemia. [Bull Exp Biol Med. 2011;151(1):82–85.]
3. Human Anxiety Reduction (2013, Zh Nevrol Psikhiatr Im S S Korsakova): Clinical study reported significant reductions in anxiety and improved cognitive test scores after 14 days of combined peptide use. [Zh Nevrol Psikhiatr. 2013;113(5):56–61.]

Packaging Information:

• Form: Lyophilized powder blend
• Purity: ≥ 99%
• Storage: Store at -20°C in a dry, dark environment
• For research use only. Not for human or veterinary use.