L-Theanine
L-Theanine
Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.
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L-Theanine — Research-Grade Amino Acid
L-Theanine (γ-Glutamylethylamide) is a non-proteinogenic amino acid primarily found in Camellia sinensis leaves. It is studied for its neuromodulatory properties—particularly its ability to promote calm alertness and influence α-wave activity in the brain without sedation.
- Chemical name: L-Theanine (γ-Glutamylethylamide)
- Molecular mass: 174.20 g/mol
- Formula: C7H14N2O3
- Appearance: White crystalline powder
- Purity: ≥ 99% (HPLC/MS verified)
- • Glutamate analogue crossing the blood–brain barrier
- • Modulates neurotransmitters (GABA, dopamine, serotonin)
- • Shown to increase α-wave activity in EEG studies
- • Commonly studied for relaxation without drowsiness
- Stress response and cortisol modulation
- Sleep latency and restorative cycles
- Attention, working memory, and reaction time
- Synergistic use with caffeine in neurocognitive models
For research applications only. Not for human use.
Background & Rationale
First isolated in 1949 from green tea, L-Theanine has since been evaluated across animal, human, and in-vitro models for its influence on glutamatergic signaling and brain wave activity. It may function as a mild antagonist at AMPA/kainate receptors and a co-agonist at NMDA receptors, supporting a state of “relaxed focus.”
Mechanistic Highlights
Neurotransmission
- Influences glutamate, GABA, dopamine, and serotonin levels in select brain regions
- Reduces excitotoxic stress in neuronal cell culture models
Physiological Outcomes
- Supports α-wave production on EEG within 30–60 min of exposure
- Attenuates sympathetic nervous activity under acute stress paradigms
Specifications & Handling
- Grade: Research-grade; ISO-audited manufacturing
- Storage (dry): 15–25 °C, airtight, away from light & moisture
- Solubility: Water soluble
- pH (1% solution): ~5–6
- Compatibility: Stable in aqueous and mild acidic solutions
- Additives: None unless specified per lot
- Packaging: Tamper-evident, lot-coded, purity-verified
Common Research Applications
Neurocognitive
- EEG alpha-wave quantification studies
- Stress-induced reaction-time paradigms
Psychophysiology
- Autonomic markers (HRV, cortisol, salivary α-amylase)
- Sleep-onset and restorative-phase research
Combination Studies
- Caffeine + L-Theanine synergy on cognition
- Neuroprotection and oxidative-stress assays
Regulatory & Use Notice
Sold for laboratory research use only. Not a dietary supplement, drug, or cosmetic. No human-use instructions are provided. Buyer is responsible for appropriate handling and regulatory compliance.
