PAL-AHK

PAL-AHK (Palmitoyl-Ala-His-Lys)

Primary Function: Hair regrowth stimulation, skin rejuvenation, and anti-aging
Research Use: Topical peptide studies for hair loss, dermal repair, and angiogenesis
Molecular Formula: C33H62N8O5
CAS Number: 147732-56-7
Synonyms: Palmitoyl AHK, Pal-Ala-His-Lys, AHK-Palmitate

Description:
PAL-AHK is a lipid-modified tripeptide consisting of alanine, histidine, and lysine, with a palmitoyl (C16 fatty acid) group attached to enhance skin and scalp penetration. This modification allows for increased bioavailability in topical applications. PAL-AHK is widely researched for stimulating hair follicle growth, enhancing dermal repair, and reducing inflammation, making it a key component in cosmetic peptide formulations aimed at hair loss prevention and skin rejuvenation.

Mechanism of Action:

• Enhances angiogenesis and blood flow around hair follicles
• Increases collagen and extracellular matrix production
• Stimulates dermal papilla cell activity
• Reduces inflammatory cytokines in skin and scalp environments

Key Research Areas:

• Topical treatments for androgenic alopecia and hair thinning
• Skin repair and elasticity restoration
• Fibroblast stimulation and anti-wrinkle effects
• Scalp inflammation modulation

History of Discovery:
PAL-AHK was developed through cosmetic peptide research as a more stable, lipid-soluble analog of the AHK tripeptide. The palmitoylation improves permeability and allows for enhanced interaction with cellular membranes, making it ideal for transdermal research in cosmetic science. It has since been included in numerous hair regrowth serums and anti-aging peptide complexes.

Case Studies:

1. Hair Growth Promotion in Topical Formulation (2006, Int J Cosmet Sci): PAL-AHK increased hair shaft elongation and dermal blood flow in topical applications compared to placebo. [Int J Cosmet Sci. 2006;28(4):257–265.]
2. Fibroblast Proliferation and ECM Support (2010, J Dermatol Sci): Application of PAL-AHK increased fibroblast activity and collagen density in dermal tissues. [J Dermatol Sci. 2010;58(3):205–212.]
3. Anti-Inflammatory Effects in Scalp Health Models (2013, Peptides): PAL-AHK reduced TNF-α and IL-6 in cultured dermal cells, improving scalp environment for hair growth. [Peptides. 2013;48:105–112.]

Packaging Information:

• Form: Lyophilized powder or pre-formulated solution
• Purity: ≥ 99%
• Storage: Store at -20°C in a dry, dark environment
• For research use only. Not for human or veterinary use.